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TMPRSS2 transmembrane serine protease 2 [ Bos taurus (domestic cattle) ]

Gene ID: 511037, updated on 5-Sep-2025
Official Symbol
TMPRSS2provided by VGNC
Official Full Name
transmembrane serine protease 2provided by VGNC
Primary source
VGNC:VGNC:36140
See related
BGD:BT22202; EnsemblRapid:ENSBTAG00070034115
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See TMPRSS2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (141711586..141758024, complement)

Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene MX dynamin like GTPase 2 Neighboring gene MX dynamin like GTPase 1 Neighboring gene keratin-associated protein 10-8-like Neighboring gene keratin-associated protein 12-2

Genomic Sequence:
NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Clone Names

  • MGC154978

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein autoprocessing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
transmembrane protease serine 2
Names
transmembrane protease, serine 2
NP_001075054.1
XP_005202057.1
XP_015329141.1
XP_015329143.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081585.1 → NP_001075054.1  transmembrane protease serine 2

    See identical proteins and their annotated locations for NP_001075054.1

    Status: PROVISIONAL

    Source sequence(s)
    BC133425
    UniProtKB/TrEMBL
    A0AAA9T040, A2VDV7
    Related
    ENSBTAP00070046821.1, ENSBTAT00070076896.1
    Conserved Domains (3) summary
    cd00112
    Location:121 → 146
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:254 → 485
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:151 → 246
    SRCR_2; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    141711586..141758024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005202000.5 → XP_005202057.1  transmembrane protease serine 2 isoform X2

    See identical proteins and their annotated locations for XP_005202057.1

    UniProtKB/TrEMBL
    A0AAA9T040, A2VDV7
    Conserved Domains (3) summary
    cd00112
    Location:121 → 146
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:254 → 485
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:151 → 246
    SRCR_2; Scavenger receptor cysteine-rich domain

  2. XM_015473657.3 → XP_015329143.1  transmembrane protease serine 2 isoform X1

    UniProtKB/TrEMBL
    A0AAA9RTF5
    Conserved Domains (4) summary
    smart00020
    Location:253 → 482
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:121 → 146
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:254 → 485
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:151 → 246
    SRCR_2; Scavenger receptor cysteine-rich domain

  3. XM_015473655.3 → XP_015329141.1  transmembrane protease serine 2 isoform X1

    UniProtKB/TrEMBL
    A0AAA9RTF5
    Conserved Domains (4) summary
    smart00020
    Location:253 → 482
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:121 → 146
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:254 → 485
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:151 → 246
    SRCR_2; Scavenger receptor cysteine-rich domain
Nucleotide Protein Strain
Heading Accession and Version

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