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IL23A interleukin 23 subunit alpha [ Bos taurus (domestic cattle) ]

Gene ID: 511022, updated on 30-Jan-2025
Official Symbol
IL23Aprovided by VGNC
Official Full Name
interleukin 23 subunit alphaprovided by VGNC
Primary source
VGNC:VGNC:30146
See related
BGD:BT11153; EnsemblRapid:ENSBTAG00070012138
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
IL-23
Orthologs
human mouse all
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See IL23A in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (57009388..57042375, complement)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene timeless circadian regulator Neighboring gene apolipoprotein F Neighboring gene apolipoprotein N Neighboring gene signal transducer and activator of transcription 2 Neighboring gene microRNA mir-2432 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene poly(A) specific ribonuclease subunit PAN2 Neighboring gene microRNA mir-12054 Neighboring gene canopy FGF signaling regulator 2 Neighboring gene citrate synthase Neighboring gene coenzyme Q10A Neighboring gene ankyrin repeat domain 52 Neighboring gene microRNA mir-2433

Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Inflammatory Th17 responses to infection with Mycobacterium avium subspecies paratuberculosis (MAP) in cattle and their potential role in development of Johne's disease. DeKuiper JL, et al. Vet Immunol Immunopathol, 2019 Dec. PMID 31733610
  2. Expressed gene sequence of bovine IL23A and IL23R. Chen C, et al. Vet Immunol Immunopathol, 2009 Apr 15. PMID 19117612
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Th17 driving cytokine IL-23 expressed by infected macrophages and associated epithelial cells may contribute to chronic inflammation during later stages of Johne's disease. [review]
    Title: Inflammatory Th17 responses to infection with Mycobacterium avium subspecies paratuberculosis (MAP) in cattle and their potential role in development of Johne's disease.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T-helper 17 cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of interleukin-23 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
interleukin-23 subunit alpha
Names
interleukin 23, alpha subunit p19

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205688.1 → NP_001192617.1  interleukin-23 subunit alpha precursor

    See identical proteins and their annotated locations for NP_001192617.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000005
    UniProtKB/TrEMBL
    B2MU62, F1MSN4
    Related
    ENSBTAP00070016450.1, ENSBTAT00070027439.1
    Conserved Domains (1) summary
    pfam16649
    Location:30 → 187
    IL23; Interleukin 23 subunit alpha

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    57009388..57042375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059886293.1 → XP_059742276.1  interleukin-23 subunit alpha isoform X1

    UniProtKB/TrEMBL
    B2MU62, F1MSN4

  2. XM_059886294.1 → XP_059742277.1  interleukin-23 subunit alpha isoform X1

    UniProtKB/TrEMBL
    B2MU62, F1MSN4

  3. XM_024991618.2 → XP_024847386.1  interleukin-23 subunit alpha isoform X1

    UniProtKB/TrEMBL
    B2MU62, F1MSN4
    Conserved Domains (1) summary
    pfam16649
    Location:30 → 187
    IL23; Interleukin 23 subunit alpha

  4. XM_059886295.1 → XP_059742278.1  interleukin-23 subunit alpha isoform X1

    UniProtKB/TrEMBL
    B2MU62, F1MSN4
Nucleotide Protein Strain
Heading Accession and Version

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