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UTP18 UTP18 small subunit processome component [ Homo sapiens (human) ]

Gene ID: 51096, updated on 3-May-2020

Summary

Official Symbol
UTP18provided by HGNC
Official Full Name
UTP18 small subunit processome componentprovided by HGNC
Primary source
HGNC:HGNC:24274
See related
Ensembl:ENSG00000011260 MIM:612816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WDR50; CGI-48
Expression
Ubiquitous expression in testis (RPKM 20.7), lymph node (RPKM 10.4) and 25 other tissues See more
Orthologs

Genomic context

See UTP18 in Genome Data Viewer
Location:
17q21.33
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (51260546..51297933)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (49337897..49375294)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene NME1-NME2 readthrough Neighboring gene NME/NM23 nucleoside diphosphate kinase 2 Neighboring gene mbt domain containing 1 Neighboring gene long intergenic non-protein coding RNA 2071 Neighboring gene long intergenic non-protein coding RNA 2072

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
Process Evidence Code Pubs
rRNA processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Pwp2p-containing subcomplex of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
U3 small nucleolar RNA-associated protein 18 homolog
Names
UTP18, small subunit (SSU) processome component, homolog
WD repeat domain 50
WD repeat-containing protein 50

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016001.3NP_057085.2  U3 small nucleolar RNA-associated protein 18 homolog

    See identical proteins and their annotated locations for NP_057085.2

    Status: VALIDATED

    Source sequence(s)
    AY007138, BC025276, BG723023, BM548967
    Consensus CDS
    CCDS42362.1
    UniProtKB/Swiss-Prot
    Q9Y5J1
    Related
    ENSP00000225298.7, ENST00000225298.12
    Conserved Domains (3) summary
    COG2319
    Location:270554
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:254294
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:230493
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    51260546..51297933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524870.2XP_011523172.1  U3 small nucleolar RNA-associated protein 18 homolog isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:270491
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:254294
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:230493
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006721930.3XP_006721993.2  U3 small nucleolar RNA-associated protein 18 homolog isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:270480
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:254294
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:230452
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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