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METTL25B methyltransferase like 25B [ Homo sapiens (human) ]

Gene ID: 51093, updated on 3-Apr-2024

Summary

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Official Symbol
METTL25Bprovided by HGNC
Official Full Name
methyltransferase like 25Bprovided by HGNC
Primary source
HGNC:HGNC:24273
See related
Ensembl:ENSG00000143303 AllianceGenome:HGNC:24273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-41; RRNAD1; C1orf66
Summary
Predicted to enable rRNA (adenine-N6,N6-)-dimethyltransferase activity. Predicted to be involved in rRNA methylation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 10.0), prostate (RPKM 8.3) and 25 other tissues See more
Orthologs
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Genomic context

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See METTL25B in Genome Data Viewer
Location:
1q23.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156728469..156736960)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155864872..155873793)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156698261..156706752)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156642834-156643494 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156643495-156644156 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156645479-156646139 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156646801-156647461 Neighboring gene nestin Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156661895-156662812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156674429-156674930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156676520-156677196 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156677875-156678551 Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156682885-156683400 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1434 Neighboring gene interferon stimulated exonuclease gene 20 like 2 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:156711011-156711988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1878 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156717051-156717748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156717749-156718446 Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156718447-156719143 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156721068-156721842 Neighboring gene heparin binding growth factor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156729657-156730190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156730191-156730723 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156736100-156736726 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:156736727-156737352 Neighboring gene proline rich mitotic checkpoint control factor Neighboring gene Sharpr-MPRA regulatory region 3718

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The relationship of alpha1-antitrypsin to inflammatory periodontal disease. Peterson RJ, et al. J Periodontol, 1979 Jan. PMID 310876
  2. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. Chapuis J, et al. Mol Psychiatry, 2009 Nov. PMID 19204726, Free PMC Article
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Lai CH, et al. Genome Res, 2000 May. PMID 10810093, Free PMC Article
  4. Discovery and refinement of loci associated with lipid levels. Willer CJ, et al. Nat Genet, 2013 Nov. PMID 24097068, Free PMC Article
  5. ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Hüttenhain R, et al. Cell Host Microbe, 2019 Jul 10. PMID 31253590, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in rRNA methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
methyltransferase-like protein 25B
Names
protein RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
ribosomal RNA adenine dimethylase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142560.2 → NP_001136032.1  methyltransferase-like protein 25B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1, which results in a frameshift and a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL590666, BX094595
    Consensus CDS
    CCDS44246.1
    UniProtKB/Swiss-Prot
    Q96FB5
    Related
    ENSP00000357201.4, ENST00000368218.8
    Conserved Domains (1) summary
    cl17173
    Location:133 → 221
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_015997.4 → NP_057081.3  methyltransferase-like protein 25B isoform 1

    See identical proteins and their annotated locations for NP_057081.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL590666, BX094595
    Consensus CDS
    CCDS1154.1
    UniProtKB/Swiss-Prot
    D3DVC7, Q4VX71, Q5SZ03, Q96FB5, Q9Y358
    Related
    ENSP00000357199.4, ENST00000368216.9
    Conserved Domains (1) summary
    pfam13679
    Location:133 → 293
    Methyltransf_32; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156728469..156736960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245234.6 → XP_005245291.1  methyltransferase-like protein 25B isoform X1

    Conserved Domains (1) summary
    pfam13679
    Location:133 → 293
    Methyltransf_32; Methyltransferase domain

  2. XM_024447421.2 → XP_024303189.1  methyltransferase-like protein 25B isoform X9

    Conserved Domains (1) summary
    cl17173
    Location:133 → 224
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_005245236.6 → XP_005245293.1  methyltransferase-like protein 25B isoform X6

    Conserved Domains (1) summary
    cl17173
    Location:133 → 222
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  4. XM_005245237.6 → XP_005245294.1  methyltransferase-like protein 25B isoform X7

    Conserved Domains (1) summary
    cl17173
    Location:133 → 221
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  5. XM_005245235.6 → XP_005245292.1  methyltransferase-like protein 25B isoform X3

    Conserved Domains (1) summary
    pfam13679
    Location:63 → 223
    Methyltransf_32; Methyltransferase domain

  6. XM_047421948.1 → XP_047277904.1  methyltransferase-like protein 25B isoform X10

  7. XM_011509600.2 → XP_011507902.1  methyltransferase-like protein 25B isoform X2

    Conserved Domains (1) summary
    pfam13679
    Location:67 → 227
    Methyltransf_32; Methyltransferase domain

  8. XM_047421932.1 → XP_047277888.1  methyltransferase-like protein 25B isoform X4

    Related
    ENSP00000429756.1, ENST00000519086.5

  9. XM_047421937.1 → XP_047277893.1  methyltransferase-like protein 25B isoform X5

  10. XM_047421943.1 → XP_047277899.1  methyltransferase-like protein 25B isoform X8

  11. XM_047421944.1 → XP_047277900.1  methyltransferase-like protein 25B isoform X8

  12. XM_017001404.2 → XP_016856893.1  methyltransferase-like protein 25B isoform X2

    Conserved Domains (1) summary
    pfam13679
    Location:67 → 227
    Methyltransf_32; Methyltransferase domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    155864872..155873793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336874.1 → XP_054192849.1  methyltransferase-like protein 25B isoform X6

  2. XM_054336871.1 → XP_054192846.1  methyltransferase-like protein 25B isoform X3

  3. XM_054336879.1 → XP_054192854.1  methyltransferase-like protein 25B isoform X10

  4. XM_054336869.1 → XP_054192844.1  methyltransferase-like protein 25B isoform X1

  5. XM_054336878.1 → XP_054192853.1  methyltransferase-like protein 25B isoform X9

  6. XM_054336875.1 → XP_054192850.1  methyltransferase-like protein 25B isoform X7

  7. XM_054336872.1 → XP_054192847.1  methyltransferase-like protein 25B isoform X4

  8. XM_054336876.1 → XP_054192851.1  methyltransferase-like protein 25B isoform X8

  9. XM_054336877.1 → XP_054192852.1  methyltransferase-like protein 25B isoform X8

  10. XM_054336870.1 → XP_054192845.1  methyltransferase-like protein 25B isoform X2

  11. XM_054336873.1 → XP_054192848.1  methyltransferase-like protein 25B isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96FB5.2 GenPept UniProtKB/Swiss-Prot:Q96FB5

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