U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

METTL25B methyltransferase like 25B [ Homo sapiens (human) ]

Gene ID: 51093, updated on 6-Nov-2022

Summary

Official Symbol
METTL25Bprovided by HGNC
Official Full Name
methyltransferase like 25Bprovided by HGNC
Primary source
HGNC:HGNC:24273
See related
Ensembl:ENSG00000143303 AllianceGenome:HGNC:24273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-41; RRNAD1; C1orf66
Summary
Predicted to enable rRNA (adenine-N6,N6-)-dimethyltransferase activity. Predicted to be involved in rRNA methylation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 10.0), prostate (RPKM 8.3) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See METTL25B in Genome Data Viewer
Location:
1q23.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156728469..156736960)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155864872..155873793)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156698261..156706752)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene nestin Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene interferon stimulated exonuclease gene 20 like 2 Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene heparin binding growth factor Neighboring gene Sharpr-MPRA regulatory region 4951

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in rRNA methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
methyltransferase-like protein 25B
Names
protein RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
ribosomal RNA adenine dimethylase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142560.2NP_001136032.1  methyltransferase-like protein 25B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1, which results in a frameshift and a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL590666, BX094595
    Consensus CDS
    CCDS44246.1
    UniProtKB/Swiss-Prot
    Q96FB5
    Related
    ENSP00000357201.4, ENST00000368218.8
    Conserved Domains (1) summary
    cl17173
    Location:133221
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_015997.4NP_057081.3  methyltransferase-like protein 25B isoform 1

    See identical proteins and their annotated locations for NP_057081.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL590666, BX094595
    Consensus CDS
    CCDS1154.1
    UniProtKB/Swiss-Prot
    Q96FB5, Q9Y358
    Related
    ENSP00000357199.4, ENST00000368216.9
    Conserved Domains (1) summary
    pfam13679
    Location:133293
    Methyltransf_32; Methyltransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156728469..156736960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245234.6XP_005245291.1  methyltransferase-like protein 25B isoform X1

    Conserved Domains (1) summary
    pfam13679
    Location:133293
    Methyltransf_32; Methyltransferase domain
  2. XM_024447421.2XP_024303189.1  methyltransferase-like protein 25B isoform X9

    Conserved Domains (1) summary
    cl17173
    Location:133224
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. XM_005245236.6XP_005245293.1  methyltransferase-like protein 25B isoform X6

    Conserved Domains (1) summary
    cl17173
    Location:133222
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  4. XM_005245237.6XP_005245294.1  methyltransferase-like protein 25B isoform X7

    Conserved Domains (1) summary
    cl17173
    Location:133221
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  5. XM_005245235.6XP_005245292.1  methyltransferase-like protein 25B isoform X3

    Conserved Domains (1) summary
    pfam13679
    Location:63223
    Methyltransf_32; Methyltransferase domain
  6. XM_047421948.1XP_047277904.1  methyltransferase-like protein 25B isoform X10

  7. XM_011509600.2XP_011507902.1  methyltransferase-like protein 25B isoform X2

    Conserved Domains (1) summary
    pfam13679
    Location:67227
    Methyltransf_32; Methyltransferase domain
  8. XM_047421932.1XP_047277888.1  methyltransferase-like protein 25B isoform X4

    Related
    ENSP00000429756.1, ENST00000519086.5
  9. XM_047421937.1XP_047277893.1  methyltransferase-like protein 25B isoform X5

  10. XM_047421943.1XP_047277899.1  methyltransferase-like protein 25B isoform X8

  11. XM_047421944.1XP_047277900.1  methyltransferase-like protein 25B isoform X8

  12. XM_017001404.2XP_016856893.1  methyltransferase-like protein 25B isoform X2

    Conserved Domains (1) summary
    pfam13679
    Location:67227
    Methyltransf_32; Methyltransferase domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    155864872..155873793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)