Format

Send to:

Choose Destination

RRNAD1 ribosomal RNA adenine dimethylase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 51093, updated on 21-Dec-2019

Summary

Official Symbol
RRNAD1provided by HGNC
Official Full Name
ribosomal RNA adenine dimethylase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:24273
See related
Ensembl:ENSG00000143303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-41; C1orf66; METTL25B
Expression
Ubiquitous expression in thyroid (RPKM 10.0), prostate (RPKM 8.3) and 25 other tissues See more
Orthologs

Genomic context

See RRNAD1 in Genome Data Viewer
Location:
1q23.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (156728469..156736960)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156698263..156706752)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene nestin Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene interferon stimulated exonuclease gene 20 like 2 Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene heparin binding growth factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
rRNA methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein RRNAD1
Names
ribosomal RNA adenine dimethylase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142560.2NP_001136032.1  protein RRNAD1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1, which results in a frameshift and a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL590666, BX094595
    Consensus CDS
    CCDS44246.1
    UniProtKB/Swiss-Prot
    Q96FB5
    Related
    ENSP00000357201.4, ENST00000368218.8
    Conserved Domains (1) summary
    cl17173
    Location:133221
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_015997.4NP_057081.3  protein RRNAD1 isoform 1

    See identical proteins and their annotated locations for NP_057081.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL590666, BX094595
    Consensus CDS
    CCDS1154.1
    UniProtKB/Swiss-Prot
    Q96FB5
    Related
    ENSP00000357199.4, ENST00000368216.9
    Conserved Domains (1) summary
    pfam13679
    Location:133293
    Methyltransf_32; Methyltransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    156728469..156736960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509600.1XP_011507902.1  protein RRNAD1 isoform X2

    Conserved Domains (1) summary
    pfam13679
    Location:67227
    Methyltransf_32; Methyltransferase domain
  2. XM_024447421.1XP_024303189.1  protein RRNAD1 isoform X7

    Conserved Domains (1) summary
    cl17173
    Location:133224
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. XM_017001406.2XP_016856895.1  protein RRNAD1 isoform X6

  4. XM_017001405.2XP_016856894.1  protein RRNAD1 isoform X6

  5. XM_005245234.5XP_005245291.1  protein RRNAD1 isoform X1

    Conserved Domains (1) summary
    pfam13679
    Location:133293
    Methyltransf_32; Methyltransferase domain
  6. XM_005245236.5XP_005245293.1  protein RRNAD1 isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:133222
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  7. XM_005245237.5XP_005245294.1  protein RRNAD1 isoform X5

    Conserved Domains (1) summary
    cl17173
    Location:133221
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  8. XM_005245235.5XP_005245292.1  protein RRNAD1 isoform X3

    Conserved Domains (1) summary
    pfam13679
    Location:63223
    Methyltransf_32; Methyltransferase domain
  9. XM_017001404.1XP_016856893.1  protein RRNAD1 isoform X2

    Conserved Domains (1) summary
    pfam13679
    Location:67227
    Methyltransf_32; Methyltransferase domain

RNA

  1. XR_426778.4 RNA Sequence

  2. XR_426777.4 RNA Sequence

Support Center