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PLLP plasmolipin [ Homo sapiens (human) ]

Gene ID: 51090, updated on 8-Dec-2022

Summary

Official Symbol
PLLPprovided by HGNC
Official Full Name
plasmolipinprovided by HGNC
Primary source
HGNC:HGNC:18553
See related
Ensembl:ENSG00000102934 MIM:600340; AllianceGenome:HGNC:18553
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PMLP; TM4SF11
Summary
Predicted to be a structural constituent of myelin sheath. Predicted to be involved in myelination. Predicted to be located in compact myelin and membrane raft. Predicted to be integral component of membrane. Biomarker of schizophrenia. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 41.3), stomach (RPKM 28.7) and 17 other tissues See more
Orthologs
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Genomic context

See PLLP in Genome Data Viewer
Location:
16q13
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57256097..57284672, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63052086..63080643, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57290009..57318584, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ring finger and SPRY domain containing 1 Neighboring gene uncharacterized LOC124903697 Neighboring gene ADP ribosylation factor like GTPase 2 binding protein Neighboring gene tRNA-Leu (anticodon CAG) 2-1 Neighboring gene tRNA-Leu (anticodon CAG) 2-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in myelination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to wounding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in compact myelin IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
plasmolipin
Names
plasma membrane proteolipid (plasmolipin)
transmembrane 4 superfamily member 11 (plasmolipin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015993.3NP_057077.1  plasmolipin

    See identical proteins and their annotated locations for NP_057077.1

    Status: VALIDATED

    Source sequence(s)
    BC002760, DA366260
    Consensus CDS
    CCDS10777.1
    UniProtKB/Swiss-Prot
    B2R9T6, Q9Y342
    UniProtKB/TrEMBL
    A0A024R6T3
    Related
    ENSP00000219207.5, ENST00000219207.10
    Conserved Domains (1) summary
    pfam01284
    Location:32160
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    57256097..57284672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    63052086..63080643 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)