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YBX2 Y-box binding protein 2 [ Homo sapiens (human) ]

Gene ID: 51087, updated on 6-Jan-2019

Summary

Official Symbol
YBX2provided by HGNC
Official Full Name
Y-box binding protein 2provided by HGNC
Primary source
HGNC:HGNC:17948
See related
Ensembl:ENSG00000006047 MIM:611447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DBPC; MSY2; CSDA3; CONTRIN
Summary
This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for this gene are located on chromosome 10 and 15. [provided by RefSeq, Feb 2012]
Expression
Restricted expression toward testis (RPKM 189.1) See more
Orthologs

Genomic context

See YBX2 in Genome Data Viewer
Location:
17p13.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (7288252..7294557, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7191571..7197876, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene claudin 7 Neighboring gene solute carrier family 2 member 4 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene G protein pathway suppressor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC45104

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
oocyte development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
translational attenuation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
Y-box-binding protein 2
Names
DNA-binding protein C
epididymis secretory sperm binding protein
germ cell specific Y-box binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015982.4NP_057066.2  Y-box-binding protein 2

    See identical proteins and their annotated locations for NP_057066.2

    Status: VALIDATED

    Source sequence(s)
    AC003688, AI805280, BC033800, DB065912
    Consensus CDS
    CCDS11098.1
    UniProtKB/Swiss-Prot
    Q9Y2T7
    Related
    ENSP00000007699.5, ENST00000007699.9
    Conserved Domains (2) summary
    pfam00313
    Location:94163
    CSD; 'Cold-shock' DNA-binding domain
    cl26247
    Location:304352
    DNA_pol3_delta2; DNA polymerase III, delta subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    7288252..7294557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024713.2XP_016880202.1  Y-box-binding protein 2 isoform X1

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