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THAP4 THAP domain containing 4 [ Homo sapiens (human) ]

Gene ID: 51078, updated on 5-Aug-2022

Summary

Official Symbol
THAP4provided by HGNC
Official Full Name
THAP domain containing 4provided by HGNC
Primary source
HGNC:HGNC:23187
See related
Ensembl:ENSG00000176946 MIM:612533; AllianceGenome:HGNC:23187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP238; CGI-36; Nb(III)
Summary
Enables several functions, including heme binding activity; identical protein binding activity; and peroxynitrite isomerase activity. Involved in nitrate metabolic process and tyrosine metabolic process. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 14.3), heart (RPKM 13.9) and 25 other tissues See more
Orthologs
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Genomic context

See THAP4 in Genome Data Viewer
Location:
2q37.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (241584405..241637576, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (242084274..242140486, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242523820..242576573, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985788 Neighboring gene serine/threonine kinase 25 Neighboring gene uncharacterized LOC105373974 Neighboring gene BOK antisense RNA 1 Neighboring gene BCL2 family apoptosis regulator BOK Neighboring gene RNA, 5S ribosomal pseudogene 122 Neighboring gene autophagy related 4B cysteine peptidase Neighboring gene deoxythymidylate kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog
Voxelwise genome-wide association study (vGWAS).
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nitric oxide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables peroxynitrite isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in nitrate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tyrosine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
peroxynitrite isomerase THAP4
Names
THAP domain-containing protein 4
epididymis secretory sperm binding protein
ferric Homo sapiens nitrobindin
hs-Nb(III)
nitrobindin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164356.2NP_001157828.1  peroxynitrite isomerase THAP4 isoform 2

    See identical proteins and their annotated locations for NP_001157828.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and represents the use of an alternate promoter, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF132970, BC069235
    Consensus CDS
    CCDS54440.1
    UniProtKB/Swiss-Prot
    Q8WY91
    Related
    ENSP00000385931.1, ENST00000402136.5
    Conserved Domains (1) summary
    cd07828
    Location:10163
    lipocalin_heme-bd-THAP4-like; heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar proteins
  2. NM_015963.6NP_057047.4  peroxynitrite isomerase THAP4 isoform 1

    See identical proteins and their annotated locations for NP_057047.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC009439, BC069235
    Consensus CDS
    CCDS2551.1
    UniProtKB/Swiss-Prot
    Q8WY91, Q9Y325
    Related
    ENSP00000385006.1, ENST00000407315.6
    Conserved Domains (3) summary
    pfam05485
    Location:486
    THAP; THAP domain
    pfam08768
    Location:422574
    DUF1794; Domain of unknown function (DUF1794)
    cl22422
    Location:312425
    SRP68-RBD; RNA-binding domain of signal recognition particle subunit 68

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    241584405..241637576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004256.2XP_016859745.1  peroxynitrite isomerase THAP4 isoform X3

  2. XM_011511291.3XP_011509593.1  peroxynitrite isomerase THAP4 isoform X2

    Conserved Domains (2) summary
    pfam05485
    Location:50110
    THAP; THAP domain
    pfam08768
    Location:446625
    DUF1794; Domain of unknown function (DUF1794)
  3. XM_005247016.5XP_005247073.4  peroxynitrite isomerase THAP4 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    242084274..242140486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)