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CUTC cutC copper transporter [ Homo sapiens (human) ]

Gene ID: 51076, updated on 1-Mar-2024

Summary

Official Symbol
CUTCprovided by HGNC
Official Full Name
cutC copper transporterprovided by HGNC
Primary source
HGNC:HGNC:24271
See related
Ensembl:ENSG00000119929 MIM:610101; AllianceGenome:HGNC:24271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-32
Summary
Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 21.2), fat (RPKM 18.2) and 25 other tissues See more
Orthologs
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Genomic context

See CUTC in Genome Data Viewer
Location:
10q24.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (99732234..99756134)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (100615224..100639117)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (101491991..101515891)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378450 Neighboring gene solute carrier family 25 member 28 Neighboring gene Sharpr-MPRA regulatory region 10719 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2697 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 7 Neighboring gene EBAG9 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3872 Neighboring gene cytochrome c oxidase assembly homolog COX15 Neighboring gene MPRA-validated peak1067 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2698 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:101544125-101545324 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:101545341-101545842 Neighboring gene Nanog homeobox pseudogene 6 Neighboring gene ATP binding cassette subfamily C member 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:101589748-101590947 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:101593724-101594923 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:101609623-101610303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3873 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:101650885-101651744 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:101665689-101666888 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:101673033-101673655 Neighboring gene dynamin binding protein Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:101673656-101674278 Neighboring gene DNMBP antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:101716073-101716720 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:101716721-101717367

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ENTPD7

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables copper ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in copper ion homeostasis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in copper ion transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein tetramerization IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
copper homeostasis protein cutC homolog
Names
cutC copper transporter homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015960.3NP_057044.2  copper homeostasis protein cutC homolog

    See identical proteins and their annotated locations for NP_057044.2

    Status: VALIDATED

    Source sequence(s)
    BC011016, BM738181, CD107559
    Consensus CDS
    CCDS7483.1
    UniProtKB/Swiss-Prot
    Q5TCZ8, Q9NTM9, Q9Y321
    Related
    ENSP00000359507.5, ENST00000370476.10
    Conserved Domains (1) summary
    COG3142
    Location:27269
    CutC; Copper homeostasis protein CutC [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    99732234..99756134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    100615224..100639117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)