U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DERA deoxyribose-phosphate aldolase [ Homo sapiens (human) ]

Gene ID: 51071, updated on 4-Dec-2022

Summary

Official Symbol
DERAprovided by HGNC
Official Full Name
deoxyribose-phosphate aldolaseprovided by HGNC
Primary source
HGNC:HGNC:24269
See related
Ensembl:ENSG00000023697 MIM:619668; AllianceGenome:HGNC:24269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEOC; CGI-26
Summary
Enables deoxyribose-phosphate aldolase activity. Involved in deoxyribonucleoside catabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine (RPKM 26.2), kidney (RPKM 24.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DERA in Genome Data Viewer
Location:
12p12.3
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (15911332..16037381)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (15788590..15914666)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (16064266..16190315)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724146 Neighboring gene serine/threonine kinase receptor associated protein Neighboring gene VISTA enhancer hs798 Neighboring gene egl-9 family hypoxia-inducible factor 3 pseudogene 1 Neighboring gene uncharacterized LOC101928362 Neighboring gene solute carrier family 15 member 5 Neighboring gene microsomal glutathione S-transferase 1 Neighboring gene SPT16 homolog, facilitates chromatin remodeling subunit pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association and admixture analysis of glaucoma in the Women's Health Initiative.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables deoxyribose-phosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables deoxyribose-phosphate aldolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables deoxyribose-phosphate aldolase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in carbohydrate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in deoxyribonucleoside catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in deoxyribonucleotide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in deoxyribose phosphate catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pentose-phosphate shunt TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
deoxyribose-phosphate aldolase
Names
2-deoxy-D-ribose 5-phosphate aldolase
2-deoxyribose-5-phosphate aldolase homolog
deoxyriboaldolase
deoxyribose-phosphate aldolase (putative)
phosphodeoxyriboaldolase
putative deoxyribose-phosphate aldolase
NP_001287708.1
NP_057038.2
XP_024304769.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300779.2NP_001287708.1  deoxyribose-phosphate aldolase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC022073, BC041328, BU928832, CB851336
    Consensus CDS
    CCDS73451.1
    UniProtKB/TrEMBL
    E9PPM8
    Related
    ENSP00000436999.1, ENST00000532964.5
    Conserved Domains (1) summary
    cl21457
    Location:50234
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
  2. NM_015954.4NP_057038.2  deoxyribose-phosphate aldolase isoform 1

    See identical proteins and their annotated locations for NP_057038.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC041328, CB851336
    Consensus CDS
    CCDS44838.1
    UniProtKB/Swiss-Prot
    Q6PHW2, Q9Y315
    Related
    ENSP00000416583.2, ENST00000428559.7
    Conserved Domains (1) summary
    cd00959
    Location:50277
    DeoC; 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    15911332..16037381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449001.2XP_024304769.1  deoxyribose-phosphate aldolase isoform X1

    UniProtKB/TrEMBL
    G3V158
    Related
    ENSP00000431757.1, ENST00000526530.1
    Conserved Domains (1) summary
    cd00959
    Location:8189
    DeoC; 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    15788590..15914666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)