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NMD3 NMD3 ribosome export adaptor [ Homo sapiens (human) ]

Gene ID: 51068, updated on 21-Dec-2019

Summary

Official Symbol
NMD3provided by HGNC
Official Full Name
NMD3 ribosome export adaptorprovided by HGNC
Primary source
HGNC:HGNC:24250
See related
Ensembl:ENSG00000169251 MIM:611021
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-07
Summary
Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Several transcript variants exist for this gene, but the full-length natures of only two have been described to date. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 18.0), urinary bladder (RPKM 15.3) and 25 other tissues See more
Orthologs

Genomic context

See NMD3 in Genome Data Viewer
Location:
3q26.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (161221290..161253532)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (160939050..160970082)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) Neighboring gene uncharacterized LOC105374186 Neighboring gene uncharacterized LOC105374187 Neighboring gene uncharacterized LOC112268450

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21053

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding, bridging IDA
Inferred from Direct Assay
more info
PubMed 
ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal large subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
ribosomal large subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of RNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to nucleolus IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal large subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal large subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
60S ribosomal export protein NMD3
Names
NMD3 homolog
hNMD3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047147.1 RefSeqGene

    Range
    5029..37271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320227.1NP_001307156.1  60S ribosomal export protein NMD3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC108738, AK225664, DB480542
    Consensus CDS
    CCDS82870.1
    UniProtKB/TrEMBL
    C9JA08
    Related
    ENSP00000417559.1, ENST00000472947.5
    Conserved Domains (3) summary
    COG1499
    Location:9388
    NMD3; NMD protein affecting ribosome stability and mRNA decay [Translation, ribosomal structure and biogenesis]
    pfam04981
    Location:17246
    NMD3; NMD3 family
    cl00266
    Location:379521
    HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...
  2. NM_015938.4NP_057022.2  60S ribosomal export protein NMD3 isoform 2

    See identical proteins and their annotated locations for NP_057022.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC013317, DB480542
    Consensus CDS
    CCDS3194.1
    UniProtKB/Swiss-Prot
    Q96D46
    Related
    ENSP00000307525.2, ENST00000351193.6
    Conserved Domains (1) summary
    pfam04981
    Location:17246
    NMD3; NMD3 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    161221290..161253532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247511.2XP_005247568.1  60S ribosomal export protein NMD3 isoform X1

    See identical proteins and their annotated locations for XP_005247568.1

    UniProtKB/Swiss-Prot
    Q96D46
    Conserved Domains (1) summary
    pfam04981
    Location:17246
    NMD3; NMD3 family
  2. XM_005247512.1XP_005247569.1  60S ribosomal export protein NMD3 isoform X1

    See identical proteins and their annotated locations for XP_005247569.1

    UniProtKB/Swiss-Prot
    Q96D46
    Conserved Domains (1) summary
    pfam04981
    Location:17246
    NMD3; NMD3 family

RNA

  1. XR_001740167.2 RNA Sequence

  2. XR_001740166.2 RNA Sequence

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