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CALHM2 calcium homeostasis modulator family member 2 [ Homo sapiens (human) ]

Gene ID: 51063, updated on 24-Nov-2020

Summary

Official Symbol
CALHM2provided by HGNC
Official Full Name
calcium homeostasis modulator family member 2provided by HGNC
Primary source
HGNC:HGNC:23493
See related
Ensembl:ENSG00000138172 MIM:612235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM26B
Expression
Ubiquitous expression in ovary (RPKM 19.8), endometrium (RPKM 13.4) and 22 other tissues See more
Orthologs

Genomic context

See CALHM2 in Genome Data Viewer
Location:
10q24.33
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (103446783..103452403, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (105206543..105212162, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit k Neighboring gene microRNA 1307 Neighboring gene programmed cell death 11 Neighboring gene calcium homeostasis modulator 1 Neighboring gene calcium homeostasis modulator 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
GeneReviews: Not available

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
calcium homeostasis modulator protein 2
Names
calcium homeostasis modulator 2
family with sequence similarity 26, member B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015916.5NP_057000.2  calcium homeostasis modulator protein 2

    See identical proteins and their annotated locations for NP_057000.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    BC000039, CA432041, DB109582
    Consensus CDS
    CCDS7549.1
    UniProtKB/Swiss-Prot
    Q9HA72
    Related
    ENSP00000260743.5, ENST00000260743.10
    Conserved Domains (1) summary
    pfam14798
    Location:7256
    Ca_hom_mod; Calcium homeostasis modulator

RNA

  1. NR_024552.2 RNA Sequence

    Status: VALIDATED

    Description
    This variant (2) contains an alternate 5' splice site, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF131810, CA432041, DB109582
  2. NR_046344.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' splice site, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK022195, BC000039, CA432041

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    103446783..103452403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016308.2XP_016871797.1  calcium homeostasis modulator protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9HA72
    Conserved Domains (1) summary
    pfam14798
    Location:9180
    Ca_hom_mod; Calcium homeostasis modulator
  2. XM_017016309.2XP_016871798.1  calcium homeostasis modulator protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9HA72
    Conserved Domains (1) summary
    pfam14798
    Location:9180
    Ca_hom_mod; Calcium homeostasis modulator
  3. XM_024448035.1XP_024303803.1  calcium homeostasis modulator protein 2 isoform X2

  4. XM_006717883.2XP_006717946.1  calcium homeostasis modulator protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006717946.1

    UniProtKB/Swiss-Prot
    Q9HA72
    Conserved Domains (1) summary
    pfam14798
    Location:7256
    Ca_hom_mod; Calcium homeostasis modulator
  5. XM_006717880.2XP_006717943.1  calcium homeostasis modulator protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006717943.1

    UniProtKB/Swiss-Prot
    Q9HA72
    Related
    ENSP00000358803.3, ENST00000369788.7
    Conserved Domains (1) summary
    pfam14798
    Location:7256
    Ca_hom_mod; Calcium homeostasis modulator
  6. XM_024448034.1XP_024303802.1  calcium homeostasis modulator protein 2 isoform X1

    Conserved Domains (1) summary
    pfam14798
    Location:7256
    Ca_hom_mod; Calcium homeostasis modulator
  7. XM_011539848.2XP_011538150.1  calcium homeostasis modulator protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011538150.1

    UniProtKB/Swiss-Prot
    Q9HA72
    Conserved Domains (1) summary
    pfam14798
    Location:7256
    Ca_hom_mod; Calcium homeostasis modulator
  8. XM_006717884.4XP_006717947.1  calcium homeostasis modulator protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006717947.1

    UniProtKB/Swiss-Prot
    Q9HA72
    Conserved Domains (1) summary
    pfam14798
    Location:9180
    Ca_hom_mod; Calcium homeostasis modulator
  9. XM_017016307.1XP_016871796.1  calcium homeostasis modulator protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9HA72
    Conserved Domains (1) summary
    pfam14798
    Location:7256
    Ca_hom_mod; Calcium homeostasis modulator
  10. XM_017016306.1XP_016871795.1  calcium homeostasis modulator protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9HA72
    Conserved Domains (1) summary
    pfam14798
    Location:7256
    Ca_hom_mod; Calcium homeostasis modulator
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