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CDK4 cyclin dependent kinase 4 [ Bos taurus (domestic cattle) ]

Gene ID: 510618, updated on 5-Sep-2025
Gene symbol
CDK4
Gene description
cyclin dependent kinase 4
See related
BGD:BT19276; EnsemblRapid:ENSBTAG00070014223
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See CDK4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (55713431..55716418)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 27 subfamily B member 1 Neighboring gene membrane associated ring-CH-type finger 9 Neighboring gene tetraspanin 31 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Fibroblast growth factor 9 (FGF9) regulation of cyclin D1 and cyclin-dependent kinase-4 in ovarian granulosa and theca cells of cattle. Totty ML, et al. Mol Cell Endocrinol, 2017 Jan 15. PMID 27816766, Free PMC Article
  2. Identification of DNA replication and cell cycle proteins that interact with PCNA. Loor G, et al. Nucleic Acids Res, 1997 Dec 15. PMID 9396813, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.
    Title: Fibroblast growth factor 9 (FGF9) regulation of cyclin D1 and cyclin-dependent kinase-4 in ovarian granulosa and theca cells of cattle.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC133903

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cyclin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
cyclin-dependent kinase 4
Names
cell division protein kinase 4
NP_001032683.1
XP_005206610.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037594.2 → NP_001032683.1  cyclin-dependent kinase 4

    See identical proteins and their annotated locations for NP_001032683.1

    Status: PROVISIONAL

    Source sequence(s)
    BC109858
    UniProtKB/Swiss-Prot
    Q32KY4
    UniProtKB/TrEMBL
    A0A3Q1MXV4
    Related
    ENSBTAP00070018865.1, ENSBTAT00070032199.1
    Conserved Domains (1) summary
    cd07863
    Location:5 → 295
    STKc_CDK4; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    55713431..55716418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005206553.5 → XP_005206610.1  cyclin-dependent kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_005206610.1

    UniProtKB/Swiss-Prot
    Q32KY4
    UniProtKB/TrEMBL
    A0A3Q1MXV4
    Conserved Domains (1) summary
    cd07863
    Location:5 → 295
    STKc_CDK4; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32KY4.1 GenPept UniProtKB/Swiss-Prot:Q32KY4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.