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TXNDC11 thioredoxin domain containing 11 [ Homo sapiens (human) ]

Gene ID: 51061, updated on 23-Nov-2021

Summary

Official Symbol
TXNDC11provided by HGNC
Official Full Name
thioredoxin domain containing 11provided by HGNC
Primary source
HGNC:HGNC:28030
See related
Ensembl:ENSG00000153066 MIM:617792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EFP1
Expression
Ubiquitous expression in fat (RPKM 51.7), thyroid (RPKM 30.4) and 25 other tissues See more
Orthologs
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Genomic context

See TXNDC11 in Genome Data Viewer
Location:
16p13.13
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (11679080..11742857, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11772939..11836713, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene lipopolysaccharide induced TNF factor Neighboring gene uncharacterized LOC107984880 Neighboring gene Sharpr-MPRA regulatory region 8349 Neighboring gene nonconserved acetylation island sequence 94 enhancer Neighboring gene stannin Neighboring gene zinc finger CCCH-type containing 7A Neighboring gene breast cancer anti-estrogen resistance 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thioredoxin domain-containing protein 11
Names
EF-hand binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303447.2NP_001290376.1  thioredoxin domain-containing protein 11 isoform 1

    See identical proteins and their annotated locations for NP_001290376.1

    Status: VALIDATED

    Source sequence(s)
    BC002856, BC013727, CN347909
    Consensus CDS
    CCDS76822.1
    UniProtKB/Swiss-Prot
    Q6PKC3
    Related
    ENSP00000349439.3, ENST00000356957.7
    Conserved Domains (3) summary
    cd02995
    Location:692794
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    cd03006
    Location:97209
    PDI_a_EFP1_N; PDIa family, N-terminal EFP1 subfamily; EFP1 is a binding partner protein of thyroid oxidase (ThOX), also called Duox. ThOX proteins are responsible for the generation of hydrogen peroxide, a crucial substrate of thyroperoxidase, which functions to ...
    cl23720
    Location:830915
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. NM_001324022.2NP_001310951.1  thioredoxin domain-containing protein 11 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC007613
    Conserved Domains (2) summary
    cd02995
    Location:451553
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    cl23720
    Location:589674
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  3. NM_001324024.2NP_001310953.1  thioredoxin domain-containing protein 11 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC007613
    UniProtKB/Swiss-Prot
    Q6PKC3
    Conserved Domains (2) summary
    cd02995
    Location:213315
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    cl23720
    Location:351436
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  4. NM_001324025.2NP_001310954.1  thioredoxin domain-containing protein 11 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC007613
    UniProtKB/Swiss-Prot
    Q6PKC3
    Conserved Domains (2) summary
    cd02995
    Location:213315
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    cl23720
    Location:351436
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  5. NM_015914.7NP_056998.4  thioredoxin domain-containing protein 11 isoform 2

    See identical proteins and their annotated locations for NP_056998.4

    Status: VALIDATED

    Source sequence(s)
    AF131780, AK027646, CN347909
    Consensus CDS
    CCDS32387.1
    UniProtKB/Swiss-Prot
    Q6PKC3
    Related
    ENSP00000283033.5, ENST00000283033.10
    Conserved Domains (4) summary
    cd02981
    Location:219323
    PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    cd02995
    Location:665767
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    cd03006
    Location:97209
    PDI_a_EFP1_N; PDIa family, N-terminal EFP1 subfamily; EFP1 is a binding partner protein of thyroid oxidase (ThOX), also called Duox. ThOX proteins are responsible for the generation of hydrogen peroxide, a crucial substrate of thyroperoxidase, which functions to ...
    cl23720
    Location:803888
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RNA

  1. NR_136671.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007613
  2. NR_136672.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007613
  3. NR_136673.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007613
  4. NR_136674.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007613

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    11679080..11742857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023268.1XP_016878757.1  thioredoxin domain-containing protein 11 isoform X2

  2. XM_011522515.2XP_011520817.1  thioredoxin domain-containing protein 11 isoform X1

    Conserved Domains (3) summary
    cd02995
    Location:705807
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    cd03006
    Location:97209
    PDI_a_EFP1_N; PDIa family, N-terminal EFP1 subfamily; EFP1 is a binding partner protein of thyroid oxidase (ThOX), also called Duox. ThOX proteins are responsible for the generation of hydrogen peroxide, a crucial substrate of thyroperoxidase, which functions to ...
    cl23720
    Location:843928
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  3. XM_011522516.3XP_011520818.1  thioredoxin domain-containing protein 11 isoform X3

    Conserved Domains (2) summary
    cd02995
    Location:491593
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    cl23720
    Location:629714
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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