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ZNF691 zinc finger protein 691 [ Homo sapiens (human) ]

Gene ID: 51058, updated on 11-Jun-2021

Summary

Official Symbol
ZNF691provided by HGNC
Official Full Name
zinc finger protein 691provided by HGNC
Primary source
HGNC:HGNC:28028
See related
Ensembl:ENSG00000164011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Zfp691
Expression
Ubiquitous expression in thyroid (RPKM 2.2), ovary (RPKM 1.8) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF691 in Genome Data Viewer
Location:
1p34.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (42846563..42852477)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43312284..43318148)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984946 Neighboring gene transmembrane protein 269 Neighboring gene small vasohibin binding protein Neighboring gene erythroblast membrane associated protein (Scianna blood group) Neighboring gene uncharacterized LOC339539 Neighboring gene transmembrane channel like 6 pseudogene Neighboring gene makorin ring finger protein 8, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242739.2NP_001229668.1  zinc finger protein 691 isoform 1

    See identical proteins and their annotated locations for NP_001229668.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AF131739, BM741761, DC378862
    Consensus CDS
    CCDS55595.1
    UniProtKB/Swiss-Prot
    Q5VV52
    Related
    ENSP00000498913.1, ENST00000651192.1
    Conserved Domains (3) summary
    COG5048
    Location:108266
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:229249
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:283305
    zf-C2H2; Zinc finger, C2H2 type
  2. NM_015911.4NP_056995.1  zinc finger protein 691 isoform 2

    See identical proteins and their annotated locations for NP_056995.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AF131739
    Consensus CDS
    CCDS476.1
    UniProtKB/Swiss-Prot
    Q5VV52
    Related
    ENSP00000361586.3, ENST00000372508.7
    Conserved Domains (4) summary
    COG5048
    Location:77235
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:252274
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:98123
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    42846563..42852477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710671.4XP_006710734.1  zinc finger protein 691 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:104262
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:225245
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:279301
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:125150
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017001402.2XP_016856891.1  zinc finger protein 691 isoform X3

    UniProtKB/TrEMBL
    Q5VV50
    Related
    ENSP00000361582.1, ENST00000372504.5
    Conserved Domains (4) summary
    COG5048
    Location:99257
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:220240
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:274296
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:120145
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017001401.2XP_016856890.1  zinc finger protein 691 isoform X1

    UniProtKB/Swiss-Prot
    Q5VV52
    Related
    ENSP00000361581.2, ENST00000372503.2
    Conserved Domains (3) summary
    COG5048
    Location:108266
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:229249
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:283305
    zf-C2H2; Zinc finger, C2H2 type
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