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LAP3 leucine aminopeptidase 3 [ Homo sapiens (human) ]

Gene ID: 51056, updated on 6-Nov-2022

Summary

Official Symbol
LAP3provided by HGNC
Official Full Name
leucine aminopeptidase 3provided by HGNC
Primary source
HGNC:HGNC:18449
See related
Ensembl:ENSG00000002549 MIM:170250; AllianceGenome:HGNC:18449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAP; PEPS; LAPEP; HEL-S-106
Summary
Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Located in cytosol; midbody; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in appendix (RPKM 73.5), lymph node (RPKM 68.4) and 24 other tissues See more
Orthologs
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Genomic context

See LAP3 in Genome Data Viewer
Location:
4p15.32
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (17577198..17607970)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (17559362..17590256)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (17578821..17609593)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene NACA pseudogene 5 Neighboring gene mediator complex subunit 28 Neighboring gene family with sequence similarity 184 member B Neighboring gene DDB1 and CUL4 associated factor 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aminopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metalloexopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
cytosol aminopeptidase
Names
cysteinylglycine-S-conjugate dipeptidase
epididymis secretory protein Li 106
leucyl aminopeptidase
peptidase S
proline aminopeptidase
prolyl aminopeptidase
NP_056991.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015907.3NP_056991.2  cytosol aminopeptidase

    See identical proteins and their annotated locations for NP_056991.2

    Status: VALIDATED

    Source sequence(s)
    AC006160
    Consensus CDS
    CCDS3422.1
    UniProtKB/Swiss-Prot
    P28838, Q9UQE3
    Related
    ENSP00000226299.4, ENST00000226299.9
    Conserved Domains (1) summary
    cd00433
    Location:33511
    Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    17577198..17607970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    17559362..17590256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)