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LAP3 leucine aminopeptidase 3 [ Homo sapiens (human) ]

Gene ID: 51056, updated on 13-Mar-2020

Summary

Official Symbol
LAP3provided by HGNC
Official Full Name
leucine aminopeptidase 3provided by HGNC
Primary source
HGNC:HGNC:18449
See related
Ensembl:ENSG00000002549 MIM:170250
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAP; PEPS; LAPEP; HEL-S-106
Expression
Ubiquitous expression in appendix (RPKM 73.5), lymph node (RPKM 68.4) and 24 other tissues See more
Orthologs

Genomic context

See LAP3 in Genome Data Viewer
Location:
4p15.32
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (17577304..17607967)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (17578927..17609590)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene clarin 2 Neighboring gene NACA pseudogene 5 Neighboring gene mediator complex subunit 28 Neighboring gene family with sequence similarity 184 member B Neighboring gene DDB1 and CUL4 associated factor 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aminopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloexopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
midbody IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 
trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytosol aminopeptidase
Names
LAP-3
epididymis secretory protein Li 106
leucyl aminopeptidase
peptidase S
proline aminopeptidase
prolyl aminopeptidase
NP_056991.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015907.2NP_056991.2  cytosol aminopeptidase

    See identical proteins and their annotated locations for NP_056991.2

    Status: VALIDATED

    Source sequence(s)
    AF061738, AK130293, BI827557, BM800626
    Consensus CDS
    CCDS3422.1
    UniProtKB/Swiss-Prot
    P28838
    Related
    ENSP00000481000.1, ENST00000618908.4
    Conserved Domains (1) summary
    cd00433
    Location:33511
    Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    17577304..17607967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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