PRLH prolactin releasing hormone [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRLHprovided by HGNC
Official Full Name: prolactin releasing hormoneprovided by HGNC
Primary source: HGNC:HGNC:17945
See related: Ensembl:ENSG00000071677 MIM:602663; AllianceGenome:HGNC:17945
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PRH; PRRP
Summary: Predicted to enable neuropeptide hormone activity and prolactin-releasing peptide receptor binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; feeding behavior; and response to peptide hormone. Predicted to act upstream of or within several processes, including fat cell differentiation; reduction of food intake in response to dietary excess; and response to insulin. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, May 2025]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 2q37.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (237566574..237567175)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (238056486..238057087)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (238475217..238475818)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reproductive Regulation of PrRPs in Teleost: The Link Between Feeding and Reproduction.
Title: Reproductive Regulation of PrRPs in Teleost: The Link Between Feeding and Reproduction.
This study demonstrates that palm(11)-PrRP31 positively affects feeding and leptin-related hypothalamic signaling.
Title: Prolactin-releasing peptide improved leptin hypothalamic signaling in obese mice.
Data indicate that formation of a primarily alpha-helical C-terminal region of prolactin releasing peptide (PrRP) is critical for receptor activation.
Title: The activity of prolactin releasing peptide correlates with its helicity.
Review discusses the ancestral relationship between prolactin-releasing hormone and the C-terminal RF-motif amide precursor peptide (C-RF).
Title: The ancestry of the prolactin-releasing hormone precursor.
PrRP has a likely role in pheochromocytomas, based on its high expression in tumor tissue
Title: Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	TAS Traceable Author Statement more info	PubMed
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IEA Inferred from Electronic Annotation more info
enables prolactin-releasing peptide receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables prolactin-releasing peptide receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within autonomic nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within eating behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within energy reserve metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in feeding behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within reduction of food intake in response to dietary excess	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to dietary excess	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to glucose	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to insulin	IEA Inferred from Electronic Annotation more info
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to peptide hormone	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tissue homeostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info

General protein information

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Preferred Names: prolactin-releasing peptide

Names: preproprolactin-releasing peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.