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PRLH prolactin releasing hormone [ Homo sapiens (human) ]

Gene ID: 51052, updated on 3-May-2025
Official Symbol
PRLHprovided by HGNC
Official Full Name
prolactin releasing hormoneprovided by HGNC
Primary source
HGNC:HGNC:17945
See related
Ensembl:ENSG00000071677 MIM:602663; AllianceGenome:HGNC:17945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRH; PRRP
Summary
Predicted to enable neuropeptide hormone activity and prolactin-releasing peptide receptor binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; feeding behavior; and response to peptide hormone. Predicted to act upstream of or within several processes, including fat cell differentiation; reduction of food intake in response to dietary excess; and response to insulin. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, May 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
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See PRLH in Genome Data Viewer
Location:
2q37.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (237566574..237567175)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (238056486..238057087)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (238475217..238475818)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene melanophilin Neighboring gene MT-ND4 pseudogene 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17367 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238450455-238450956 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238472066-238472566 Neighboring gene RNA, U6 small nuclear 1140, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:238480736-238480921 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238481515-238482050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238483169-238483868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:238485267-238485965 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:238490210-238490844 Neighboring gene RAB17, member RAS oncogene family Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:238503899-238504617 Neighboring gene RAB17 divergent transcript

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables hormone activity TAS
Traceable Author Statement
more info
PubMed 
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neuropeptide hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables prolactin-releasing peptide receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables prolactin-releasing peptide receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within autonomic nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within eating behavior IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within energy reserve metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in feeding behavior IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in feeding behavior IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within reduction of food intake in response to dietary excess IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to dietary excess IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to glucose IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to insulin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within tissue homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
Preferred Names
prolactin-releasing peptide
Names
preproprolactin-releasing peptide

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015893.1NP_056977.1  prolactin-releasing peptide precursor

    See identical proteins and their annotated locations for NP_056977.1

    Status: VALIDATED

    Source sequence(s)
    AB015419
    Consensus CDS
    CCDS2519.1
    UniProtKB/Swiss-Prot
    P81277
    UniProtKB/TrEMBL
    Q53QV7
    Related
    ENSP00000165524.1, ENST00000165524.1
    Conserved Domains (1) summary
    pfam15172
    Location:2968
    Prolactin_RP; Prolactin-releasing peptide

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    237566574..237567175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    238056486..238057087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)