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PRLH prolactin releasing hormone [ Homo sapiens (human) ]

Gene ID: 51052, updated on 25-Jan-2022

Summary

Official Symbol
PRLHprovided by HGNC
Official Full Name
prolactin releasing hormoneprovided by HGNC
Primary source
HGNC:HGNC:17945
See related
Ensembl:ENSG00000071677 MIM:602663; AllianceGenome:HGNC:17945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRH; PRRP
Summary
Predicted to enable neuropeptide hormone activity and prolactin-releasing peptide receptor binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; feeding behavior; and response to peptide hormone. Predicted to act upstream of or within several processes, including energy reserve metabolic process; fat cell differentiation; and reduction of food intake in response to dietary excess. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See PRLH in Genome Data Viewer
Location:
2q37.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (237566574..237567175)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (238475217..238475818)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene melanophilin Neighboring gene MT-ND4 pseudogene 40 Neighboring gene RNA, U6 small nuclear 1140, pseudogene Neighboring gene RAB17, member RAS oncogene family Neighboring gene RAB17 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity TAS
Traceable Author Statement
more info
PubMed 
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables prolactin-releasing peptide receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autonomic nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in energy reserve metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in feeding behavior IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in reduction of food intake in response to dietary excess IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucose IEA
Inferred from Electronic Annotation
more info
 
involved_in response to insulin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tissue homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prolactin-releasing peptide
Names
preproprolactin-releasing peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015893.1NP_056977.1  prolactin-releasing peptide precursor

    See identical proteins and their annotated locations for NP_056977.1

    Status: VALIDATED

    Source sequence(s)
    AB015419
    Consensus CDS
    CCDS2519.1
    UniProtKB/Swiss-Prot
    P81277
    UniProtKB/TrEMBL
    Q53QV7
    Related
    ENSP00000165524.1, ENST00000165524.1
    Conserved Domains (1) summary
    pfam15172
    Location:2968
    Prolactin_RP; Prolactin-releasing peptide

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    237566574..237567175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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