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PI15 peptidase inhibitor 15 [ Homo sapiens (human) ]

Gene ID: 51050, updated on 1-Aug-2020

Summary

Official Symbol
PI15provided by HGNC
Official Full Name
peptidase inhibitor 15provided by HGNC
Primary source
HGNC:HGNC:8946
See related
Ensembl:ENSG00000137558 MIM:607076
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P24TI; P25TI; CRISP8
Summary
This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008]
Expression
Biased expression in appendix (RPKM 36.9), prostate (RPKM 13.1) and 3 other tissues See more
Orthologs

Genomic context

See PI15 in Genome Data Viewer
Location:
8q21.13
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (74824534..74855029)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (75736772..75767264)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375904 Neighboring gene MIR2052 host gene Neighboring gene poly(rC) binding protein 2 pseudogene 2 Neighboring gene microRNA 2052 Neighboring gene cysteine rich secretory protein LCCL domain containing 1 Neighboring gene uncharacterized LOC105375905

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

General gene information

Markers

Homology

Clone Names

  • DKFZp686F0366

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
peptidase inhibitor 15
Names
25 kDa trypsin inhibitor
CRISP-8
PI-15
cysteine-rich secretory protein 8
protease inhibitor 15
sugarCrisp

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324403.2NP_001311332.1  peptidase inhibitor 15 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC011632, AC026616
    Consensus CDS
    CCDS6218.1
    UniProtKB/Swiss-Prot
    O43692
    Related
    ENSP00000497041.1, ENST00000649643.1
    Conserved Domains (1) summary
    cd05380
    Location:69212
    SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...
  2. NM_015886.5NP_056970.1  peptidase inhibitor 15 preproprotein

    See identical proteins and their annotated locations for NP_056970.1

    Status: REVIEWED

    Source sequence(s)
    AC011632, AC026616, CR749657, D45027
    Consensus CDS
    CCDS6218.1
    UniProtKB/Swiss-Prot
    O43692
    Related
    ENSP00000260113.2, ENST00000260113.7
    Conserved Domains (1) summary
    cd05380
    Location:69212
    SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    74824534..74855029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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