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SERPINA5 serpin family A member 5 [ Homo sapiens (human) ]

Gene ID: 5104, updated on 18-Sep-2024

Summary

Official Symbol
SERPINA5provided by HGNC
Official Full Name
serpin family A member 5provided by HGNC
Primary source
HGNC:HGNC:8723
See related
Ensembl:ENSG00000188488 MIM:601841; AllianceGenome:HGNC:8723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCI; PAI3; PAI-3; PCI-B; PROCI; PLANH3
Summary
The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]
Expression
Biased expression in testis (RPKM 322.5), adrenal (RPKM 213.7) and 6 other tissues See more
Orthologs
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Genomic context

See SERPINA5 in Genome Data Viewer
Location:
14q32.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (94581426..94593118)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (88811397..88823118)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (95047763..95059455)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903410 Neighboring gene serpin family A member 4 Neighboring gene uncharacterized LOC112268127 Neighboring gene uncharacterized LOC124903411 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:95065522-95066360 Neighboring gene serpin family A member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acrosin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables glycosaminoglycan binding TAS
Traceable Author Statement
more info
PubMed 
enables heparin binding TAS
Traceable Author Statement
more info
PubMed 
enables phosphatidylcholine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables retinoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in fusion of sperm to egg plasma membrane involved in single fertilization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in acrosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in platelet alpha granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in platelet dense tubular network IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein C inhibitor-KLK3 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein C inhibitor-PLAT complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein C inhibitor-PLAU complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein C inhibitor-TMPRSS11E complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein C inhibitor-TMPRSS7 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein C inhibitor-coagulation factor V complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein C inhibitor-coagulation factor XI complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein C inhibitor-coagulation factor Xa complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein C inhibitor-plasma kallikrein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein C inhibitor-thrombin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
plasma serine protease inhibitor
Names
acrosomal serine protease inhibitor
plasminogen activator inhibitor III
plasminogen activator inhibitor-3
protein C inhibitor
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032908.2 RefSeqGene

    Range
    24985..36677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_644

mRNA and Protein(s)

  1. NM_000624.6NP_000615.3  plasma serine protease inhibitor preproprotein

    See identical proteins and their annotated locations for NP_000615.3

    Status: REVIEWED

    Source sequence(s)
    AI114432, AK293192, BC008915, DC394575, HY003178
    Consensus CDS
    CCDS9928.1
    UniProtKB/Swiss-Prot
    P05154, Q07616, Q9UG30
    UniProtKB/TrEMBL
    B3KTV6
    Related
    ENSP00000333203.7, ENST00000329597.12
    Conserved Domains (1) summary
    cd02056
    Location:44403
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    94581426..94593118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    88811397..88823118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)