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SERPINA5 serpin family A member 5 [ Homo sapiens (human) ]

Gene ID: 5104, updated on 7-Dec-2018

Summary

Official Symbol
SERPINA5provided by HGNC
Official Full Name
serpin family A member 5provided by HGNC
Primary source
HGNC:HGNC:8723
See related
Ensembl:ENSG00000188488 MIM:601841
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCI; PAI3; PAI-3; PCI-B; PROCI; PLANH3
Summary
The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]
Expression
Biased expression in testis (RPKM 322.5), adrenal (RPKM 213.7) and 6 other tissues See more
Orthologs

Genomic context

See SERPINA5 in Genome Data Viewer
Location:
14q32.13
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (94581369..94593120)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (95047706..95059457)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene serpin family A member 12 Neighboring gene serpin family A member 4 Neighboring gene uncharacterized LOC112268127 Neighboring gene serpin family A member 3 Neighboring gene adiponectin receptor 1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Common Pathway of Fibrin Clot Formation, organism-specific biosystem (from REACTOME)
    Common Pathway of Fibrin Clot Formation, organism-specific biosystemThe common pathway consists of the cascade of activation events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the f...
  • Complement and Coagulation Cascades, organism-specific biosystem (from WikiPathways)
    Complement and Coagulation Cascades, organism-specific biosystemBlood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the for...
  • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
    Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Complement and coagulation cascades, conserved biosystem (from KEGG)
    Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem (from REACTOME)
    Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystemThe formation of a fibrin clot at the site of an injury to the wall of a normal blood vessel is an essential part of the process to stop blood loss after vascular injury. The reactions that lead to ...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Intrinsic Pathway of Fibrin Clot Formation, organism-specific biosystem (from REACTOME)
    Intrinsic Pathway of Fibrin Clot Formation, organism-specific biosystemThe intrinsic pathway of blood clotting connects interactions among kininogen (high molecular weight kininogen, HK), prekallikrein (PK), and factor XII to the activation of clotting factor X by a ser...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acrosin binding IPI
Inferred from Physical Interaction
more info
PubMed 
glycosaminoglycan binding TAS
Traceable Author Statement
more info
PubMed 
heparin binding TAS
Traceable Author Statement
more info
PubMed 
phosphatidylcholine binding IDA
Inferred from Direct Assay
more info
PubMed 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
blood coagulation TAS
Traceable Author Statement
more info
 
fusion of sperm to egg plasma membrane involved in single fertilization NAS
Non-traceable Author Statement
more info
PubMed 
lipid transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
seminal vesicle development IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
acrosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule IDA
Inferred from Direct Assay
more info
PubMed 
platelet dense tubular network IDA
Inferred from Direct Assay
more info
PubMed 
protein C inhibitor-KLK3 complex IDA
Inferred from Direct Assay
more info
PubMed 
protein C inhibitor-PLAT complex IDA
Inferred from Direct Assay
more info
PubMed 
protein C inhibitor-PLAU complex IDA
Inferred from Direct Assay
more info
PubMed 
protein C inhibitor-TMPRSS11E complex IDA
Inferred from Direct Assay
more info
PubMed 
protein C inhibitor-TMPRSS7 complex IDA
Inferred from Direct Assay
more info
PubMed 
protein C inhibitor-coagulation factor V complex IDA
Inferred from Direct Assay
more info
PubMed 
protein C inhibitor-coagulation factor XI complex IDA
Inferred from Direct Assay
more info
PubMed 
protein C inhibitor-coagulation factor Xa complex IDA
Inferred from Direct Assay
more info
PubMed 
protein C inhibitor-plasma kallikrein complex IDA
Inferred from Direct Assay
more info
PubMed 
protein C inhibitor-thrombin complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
plasma serine protease inhibitor
Names
acrosomal serine protease inhibitor
plasminogen activator inhibitor III
plasminogen activator inhibitor-3
protein C inhibitor
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032908.2 RefSeqGene

    Range
    24928..36679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000624.6NP_000615.3  plasma serine protease inhibitor preproprotein

    See identical proteins and their annotated locations for NP_000615.3

    Status: REVIEWED

    Source sequence(s)
    AI114432, AK293192, BC008915, DC394575, HY003178
    Consensus CDS
    CCDS9928.1
    UniProtKB/Swiss-Prot
    P05154
    UniProtKB/TrEMBL
    A0A024R6N9, B4DDH1
    Related
    ENSP00000333203.7, ENST00000329597.11
    Conserved Domains (1) summary
    cd02056
    Location:44403
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    94581369..94593120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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