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UBXN1 UBX domain protein 1 [ Homo sapiens (human) ]

Gene ID: 51035, updated on 4-Oct-2020

Summary

Official Symbol
UBXN1provided by HGNC
Official Full Name
UBX domain protein 1provided by HGNC
Primary source
HGNC:HGNC:18402
See related
Ensembl:ENSG00000162191 MIM:616378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
2B28; SAKS1; UBXD10
Expression
Ubiquitous expression in ovary (RPKM 47.6), fat (RPKM 40.5) and 25 other tissues See more
Orthologs

Genomic context

See UBXN1 in Genome Data Viewer
Location:
11q12.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62676500..62679116, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62443972..62446554, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene LBH domain containing 1 Neighboring gene small nucleolar RNA, H/ACA box 57 Neighboring gene citrate synthase lysine methyltransferase Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 3 Neighboring gene HNRNPUL2-BSCL2 readthrough (NMD candidate) Neighboring gene LRRN4 C-terminal like Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin Neighboring gene G protein subunit gamma 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
VCP-NPL4-UFD1 AAA ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
UBX domain-containing protein 1
Names
SAPK substrate protein 1
UBA/UBX 33.3 kDa protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286077.2NP_001273006.1  UBX domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001273006.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon structure in the 3' region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC040129
    Consensus CDS
    CCDS66105.1
    UniProtKB/Swiss-Prot
    Q04323
    UniProtKB/TrEMBL
    A0A024R598
    Related
    ENSP00000303991.5, ENST00000301935.9
    Conserved Domains (2) summary
    cd01772
    Location:210293
    SAKS1_UBX; SAKS1-like UBX domain
    cd14302
    Location:545
    UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins
  2. NM_001286078.2NP_001273007.1  UBX domain-containing protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' region and contains an alternate exon structure in the 3' region, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC040129, BI855821, BP329601
    Consensus CDS
    CCDS73307.1
    UniProtKB/Swiss-Prot
    Q04323
    UniProtKB/TrEMBL
    A0A087WTZ5
    Related
    ENSP00000478250.1, ENST00000616865.4
    Conserved Domains (2) summary
    cd01772
    Location:151234
    SAKS1_UBX; SAKS1-like UBX domain
    cd14302
    Location:541
    UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins
  3. NM_015853.5NP_056937.2  UBX domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_056937.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC001372, BP329601
    Consensus CDS
    CCDS8029.1
    UniProtKB/Swiss-Prot
    Q04323
    UniProtKB/TrEMBL
    A0A024R539
    Related
    ENSP00000294119.2, ENST00000294119.6
    Conserved Domains (2) summary
    cd14302
    Location:545
    UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins
    cl00155
    Location:210283
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    62676500..62679116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017874.1XP_016873363.1  UBX domain-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q04323
    UniProtKB/TrEMBL
    A0A024R598
    Related
    ENSP00000435625.1, ENST00000534176.1
    Conserved Domains (2) summary
    cd01772
    Location:210293
    SAKS1_UBX; SAKS1-like UBX domain
    cd14302
    Location:545
    UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins
  2. XM_005274033.4XP_005274090.1  UBX domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005274090.1

    UniProtKB/Swiss-Prot
    Q04323
    UniProtKB/TrEMBL
    A0A024R539
    Conserved Domains (2) summary
    cd14302
    Location:545
    UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins
    cl00155
    Location:210283
    UBQ; Ubiquitin-like proteins
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