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CELA2B chymotrypsin like elastase 2B [ Homo sapiens (human) ]

Gene ID: 51032, updated on 5-Aug-2022

Summary

Official Symbol
CELA2Bprovided by HGNC
Official Full Name
chymotrypsin like elastase 2Bprovided by HGNC
Primary source
HGNC:HGNC:29995
See related
Ensembl:ENSG00000215704 MIM:609444; AllianceGenome:HGNC:29995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ELA2B
Summary
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward pancreas (RPKM 4511.4) See more
Orthologs
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Genomic context

See CELA2B in Genome Data Viewer
Location:
1p36.21
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (15476104..15491395)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (14920804..14936095)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (15802599..15817890)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chymotrypsin C Neighboring gene uncharacterized LOC105376767 Neighboring gene chymotrypsin like elastase 2A Neighboring gene caspase 9 Neighboring gene Sharpr-MPRA regulatory region 4011 Neighboring gene DnaJ heat shock protein family (Hsp40) member C16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CELA2A

Homology

Clone Names

  • MGC97052, MGC142100, MGC142102

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
chymotrypsin-like elastase family member 2B
Names
RP11-265F14.2
chymotrypsin like elastase family member 2B
elastase 2B
pancreatic elastase IIB (ELA2B)
NP_056933.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015849.3NP_056933.3  chymotrypsin-like elastase family member 2B preproprotein

    Status: REVIEWED

    Source sequence(s)
    AL512883
    Consensus CDS
    CCDS30605.1
    UniProtKB/Swiss-Prot
    Q96QV5
    Related
    ENSP00000365075.3, ENST00000375910.8
    Conserved Domains (1) summary
    cd00190
    Location:31265
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    15476104..15491395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    14920804..14936095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)