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GLOD4 glyoxalase domain containing 4 [ Homo sapiens (human) ]

Gene ID: 51031, updated on 23-Nov-2021

Summary

Official Symbol
GLOD4provided by HGNC
Official Full Name
glyoxalase domain containing 4provided by HGNC
Primary source
HGNC:HGNC:14111
See related
Ensembl:ENSG00000167699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HC71; CGI-150; C17orf25
Expression
Ubiquitous expression in kidney (RPKM 28.9), duodenum (RPKM 28.6) and 25 other tissues See more
Orthologs
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Genomic context

See GLOD4 in Genome Data Viewer
Location:
17p13.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (759321..789830, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (662570..685520, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TLC domain containing 3A Neighboring gene gem nuclear organelle associated protein 4 Neighboring gene diazepam binding inhibitor-like 5, pseudogene Neighboring gene Sharpr-MPRA regulatory region 8532 Neighboring gene mitochondrial rRNA methyltransferase 3 Neighboring gene nucleoredoxin Neighboring gene uncharacterized LOC101927727 Neighboring gene Sharpr-MPRA regulatory region 13189

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glyoxalase domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366247.2NP_001353176.1  glyoxalase domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Related
    ENSP00000301328.5, ENST00000301328.9
    Conserved Domains (2) summary
    cd16357
    Location:155270
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:4145
    VOC; vicinal oxygen chelate (VOC) family
  2. NM_001366248.2NP_001353177.1  glyoxalase domain-containing protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Conserved Domains (2) summary
    cd16357
    Location:84199
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:174
    VOC; vicinal oxygen chelate (VOC) family
  3. NM_001366249.2NP_001353178.1  glyoxalase domain-containing protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Conserved Domains (2) summary
    cd16357
    Location:131246
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:39121
    VOC; vicinal oxygen chelate (VOC) family
  4. NM_001366250.2NP_001353179.1  glyoxalase domain-containing protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Conserved Domains (2) summary
    cd16357
    Location:131246
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:39121
    VOC; vicinal oxygen chelate (VOC) family
  5. NM_001389725.1NP_001376654.1  glyoxalase domain-containing protein 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Conserved Domains (2) summary
    cd16357
    Location:206321
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:4196
    VOC; vicinal oxygen chelate (VOC) family
  6. NM_001389726.1NP_001376655.1  glyoxalase domain-containing protein 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Conserved Domains (2) summary
    cd16357
    Location:177292
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:4167
    VOC; vicinal oxygen chelate (VOC) family
  7. NM_001389727.1NP_001376656.1  glyoxalase domain-containing protein 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Conserved Domains (2) summary
    cd08358
    Location:4130
    GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cd16357
    Location:140255
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
  8. NM_001389728.1NP_001376657.1  glyoxalase domain-containing protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Conserved Domains (2) summary
    cd16357
    Location:131246
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:39121
    VOC; vicinal oxygen chelate (VOC) family
  9. NM_001389729.1NP_001376658.1  glyoxalase domain-containing protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Conserved Domains (2) summary
    cd16357
    Location:131246
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:39121
    VOC; vicinal oxygen chelate (VOC) family
  10. NM_001389730.1NP_001376659.1  glyoxalase domain-containing protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Conserved Domains (2) summary
    cd16357
    Location:131246
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:39121
    VOC; vicinal oxygen chelate (VOC) family
  11. NM_001389731.1NP_001376660.1  glyoxalase domain-containing protein 4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Conserved Domains (2) summary
    cd08358
    Location:4130
    GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cd16357
    Location:140242
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
  12. NM_001389732.1NP_001376661.1  glyoxalase domain-containing protein 4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Conserved Domains (2) summary
    cd08358
    Location:4130
    GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cd16357
    Location:140248
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
  13. NM_001389733.1NP_001376662.1  glyoxalase domain-containing protein 4 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Conserved Domains (2) summary
    cd08358
    Location:4130
    GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cd16357
    Location:140236
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
  14. NM_001389734.1NP_001376663.1  glyoxalase domain-containing protein 4 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Conserved Domains (2) summary
    cd08358
    Location:4130
    GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cd16357
    Location:140226
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
  15. NM_001389735.1NP_001376664.1  glyoxalase domain-containing protein 4 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Conserved Domains (2) summary
    cd08358
    Location:4130
    GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:140217
    VOC; vicinal oxygen chelate (VOC) family
  16. NM_001389736.1NP_001376665.1  glyoxalase domain-containing protein 4 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Related
    ENSP00000460634.1, ENST00000576419.1
    Conserved Domains (2) summary
    cd08358
    Location:4130
    GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:140210
    VOC; vicinal oxygen chelate (VOC) family
  17. NM_016080.4NP_057164.3  glyoxalase domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_057164.3

    Status: VALIDATED

    Source sequence(s)
    AF061730, BC008605, DA608953
    Consensus CDS
    CCDS32520.1
    UniProtKB/Swiss-Prot
    Q9HC38
    Related
    ENSP00000301329.6, ENST00000301329.10
    Conserved Domains (2) summary
    cd08358
    Location:4130
    GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cd16357
    Location:140255
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    759321..789830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450778.1XP_024306546.1  glyoxalase domain-containing protein 4 isoform X1

    Conserved Domains (2) summary
    cd16357
    Location:131246
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:39121
    VOC; vicinal oxygen chelate (VOC) family
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