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TVP23B trans-golgi network vesicle protein 23 homolog B [ Homo sapiens (human) ]

Gene ID: 51030, updated on 5-Sep-2021

Summary

Official Symbol
TVP23Bprovided by HGNC
Official Full Name
trans-golgi network vesicle protein 23 homolog Bprovided by HGNC
Primary source
HGNC:HGNC:20399
See related
Ensembl:ENSG00000171928
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM18B; NPD008; CGI-148; FAM18B1; YDR084C
Expression
Ubiquitous expression in thyroid (RPKM 19.1), adrenal (RPKM 15.3) and 25 other tissues See more
Orthologs
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Genomic context

See TVP23B in Genome Data Viewer
Location:
17p11.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (18781183..18806714)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (18684496..18710027)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 16 like Neighboring gene Sharpr-MPRA regulatory region 2370 Neighboring gene F-box and WD repeat domain containing 10 Neighboring gene coiled-coil domain-containing protein 144A-like Neighboring gene RNA, 7SL, cytoplasmic 627, pseudogene Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 2 Neighboring gene RAN binding protein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ46240

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in integral component of Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Golgi apparatus membrane protein TVP23 homolog B
Names
family with sequence similarity 18, member B
family with sequence similarity 18, member B1
protein FAM18B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316919.1NP_001303848.1  Golgi apparatus membrane protein TVP23 homolog B isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC107982, BC008430, BX648167
    Consensus CDS
    CCDS82084.1
    UniProtKB/Swiss-Prot
    Q9NYZ1
    UniProtKB/TrEMBL
    J3QL63
    Related
    ENSP00000463400.2, ENST00000476139.5
    Conserved Domains (1) summary
    pfam05832
    Location:1110
    DUF846; Eukaryotic protein of unknown function (DUF846)
  2. NM_001316920.1NP_001303849.1  Golgi apparatus membrane protein TVP23 homolog B isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    BC008430, DA067248
    Consensus CDS
    CCDS82084.1
    UniProtKB/Swiss-Prot
    Q9NYZ1
    UniProtKB/TrEMBL
    J3QL63
    Related
    ENSP00000465872.1, ENST00000581733.1
    Conserved Domains (1) summary
    pfam05832
    Location:1110
    DUF846; Eukaryotic protein of unknown function (DUF846)
  3. NM_001316921.2NP_001303850.1  Golgi apparatus membrane protein TVP23 homolog B isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC107982, BC008430, CN390782, DB143840
    Consensus CDS
    CCDS82084.1
    UniProtKB/Swiss-Prot
    Q9NYZ1
    UniProtKB/TrEMBL
    J3QL63
    Related
    ENSP00000467001.1, ENST00000575261.5
    Conserved Domains (1) summary
    pfam05832
    Location:1110
    DUF846; Eukaryotic protein of unknown function (DUF846)
  4. NM_001316922.2NP_001303851.1  Golgi apparatus membrane protein TVP23 homolog B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (c).
    Source sequence(s)
    AC107982, BC008430, BQ433266, DB143840
    UniProtKB/Swiss-Prot
    Q9NYZ1
    Conserved Domains (1) summary
    pfam05832
    Location:188
    DUF846; Eukaryotic protein of unknown function (DUF846)
  5. NM_001316923.2NP_001303852.1  Golgi apparatus membrane protein TVP23 homolog B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (c).
    Source sequence(s)
    AC107982, BC008430, DA773045, DB143840
    UniProtKB/Swiss-Prot
    Q9NYZ1
    Conserved Domains (1) summary
    pfam05832
    Location:188
    DUF846; Eukaryotic protein of unknown function (DUF846)
  6. NM_001316924.2NP_001303853.1  Golgi apparatus membrane protein TVP23 homolog B isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an exon in place of the last two exons compared to variant 1. The resulting isoform (d) is shorter at the C-terminus compared to isoform a.
    Source sequence(s)
    AC107982, DA551966, DB143840
    UniProtKB/Swiss-Prot
    Q9NYZ1
    Conserved Domains (1) summary
    pfam05832
    Location:32154
    DUF846; Eukaryotic protein of unknown function (DUF846)
  7. NM_016078.6NP_057162.4  Golgi apparatus membrane protein TVP23 homolog B isoform a

    See identical proteins and their annotated locations for NP_057162.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC107982, BC008430, DB143840
    Consensus CDS
    CCDS42274.1
    UniProtKB/Swiss-Prot
    Q9NYZ1
    Related
    ENSP00000305654.8, ENST00000307767.13
    Conserved Domains (1) summary
    pfam05832
    Location:32174
    DUF846; Eukaryotic protein of unknown function (DUF846)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    18781183..18806714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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