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FIS1 fission, mitochondrial 1 [ Homo sapiens (human) ]

Gene ID: 51024, updated on 24-Nov-2020

Summary

Official Symbol
FIS1provided by HGNC
Official Full Name
fission, mitochondrial 1provided by HGNC
Primary source
HGNC:HGNC:21689
See related
Ensembl:ENSG00000214253 MIM:609003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTC11; CGI-135
Summary
The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in heart (RPKM 77.0), thyroid (RPKM 71.6) and 25 other tissues See more
Orthologs

Genomic context

See FIS1 in Genome Data Viewer
Location:
7q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (101239472..101245081, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100882893..100889009, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger HIT-type containing 1 Neighboring gene claudin 15 Neighboring gene RNA, U6 small nuclear 1104, pseudogene Neighboring gene AZGP1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 encephalitis infection downregulates FIS1 protein levels in post-mortem brain samples PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Env (gp120) downregulates FIS1 protein levels in transgenic mouse neurons PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagy of mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
calcium-mediated signaling using intracellular calcium source IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to peptide IEA
Inferred from Electronic Annotation
more info
 
cellular response to thapsigargin IEA
Inferred from Electronic Annotation
more info
 
cellular response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial fission IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial fragmentation involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial fragmentation involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial fragmentation involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ATP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endoplasmic reticulum calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
peroxisome fission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisome fission IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitochondrial calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitochondrial fission IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein targeting to membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to flavonoid IEA
Inferred from Electronic Annotation
more info
 
response to fluoride IEA
Inferred from Electronic Annotation
more info
 
response to hypobaric hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to muscle activity IEA
Inferred from Electronic Annotation
more info
 
response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of mitochondrial outer membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial fission 1 protein
Names
FIS1 homolog
H_NH0132A01.6
TPR repeat protein 11
fission 1 (mitochondrial outer membrane) homolog
hFis1
mitochondrial fission molecule
tetratricopeptide repeat domain 11
tetratricopeptide repeat protein 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016068.3NP_057152.2  mitochondrial fission 1 protein

    See identical proteins and their annotated locations for NP_057152.2

    Status: VALIDATED

    Source sequence(s)
    AC006329, BC009428, BI836529
    Consensus CDS
    CCDS43626.1
    UniProtKB/Swiss-Prot
    Q9Y3D6
    Related
    ENSP00000223136.4, ENST00000223136.5
    Conserved Domains (1) summary
    cd12212
    Location:9123
    Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    101239472..101245081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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