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FIS1 fission, mitochondrial 1 [ Homo sapiens (human) ]

Gene ID: 51024, updated on 22-Sep-2022

Summary

Official Symbol
FIS1provided by HGNC
Official Full Name
fission, mitochondrial 1provided by HGNC
Primary source
HGNC:HGNC:21689
See related
Ensembl:ENSG00000214253 MIM:609003; AllianceGenome:HGNC:21689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTC11; CGI-135
Summary
The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in heart (RPKM 77.0), thyroid (RPKM 71.6) and 25 other tissues See more
Orthologs
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Genomic context

See FIS1 in Genome Data Viewer
Location:
7q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (101239472..101245081, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (102562935..102568544, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100882753..100888362, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger HIT-type containing 1 Neighboring gene claudin 15 Neighboring gene RNA, U6 small nuclear 1104, pseudogene Neighboring gene AZGP1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 encephalitis infection downregulates FIS1 protein levels in post-mortem brain samples PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Env (gp120) downregulates FIS1 protein levels in transgenic mouse neurons PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lipid binding EXP
Inferred from Experiment
more info
PubMed 
enables molecular adaptor activity EXP
Inferred from Experiment
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagy of mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium-mediated signaling using intracellular calcium source IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial fission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fragmentation involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial fragmentation involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial fragmentation involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ATP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endoplasmic reticulum calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peroxisome fission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peroxisome fission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peroxisome fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrial calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrial fission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein targeting to membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisomal membrane TAS
Traceable Author Statement
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial fission 1 protein
Names
FIS1 homolog
H_NH0132A01.6
TPR repeat protein 11
fission 1 (mitochondrial outer membrane) homolog
hFis1
mitochondrial fission molecule
tetratricopeptide repeat domain 11
tetratricopeptide repeat protein 11

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016068.3NP_057152.2  mitochondrial fission 1 protein

    See identical proteins and their annotated locations for NP_057152.2

    Status: VALIDATED

    Source sequence(s)
    AC006329, BC009428, BI836529
    Consensus CDS
    CCDS43626.1
    UniProtKB/Swiss-Prot
    Q9BTP3, Q9Y3D6
    Related
    ENSP00000223136.4, ENST00000223136.5
    Conserved Domains (1) summary
    cd12212
    Location:9123
    Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    101239472..101245081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    102562935..102568544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)