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MRPS18C mitochondrial ribosomal protein S18C [ Homo sapiens (human) ]

Gene ID: 51023, updated on 2-Mar-2021

Summary

Official Symbol
MRPS18Cprovided by HGNC
Official Full Name
mitochondrial ribosomal protein S18Cprovided by HGNC
Primary source
HGNC:HGNC:16633
See related
Ensembl:ENSG00000163319 MIM:611983
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-134; S18mt-c; MRPS18-1; mrps18-c; MRP-S18-1; MRP-S18-c
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 8p, 12p, 15q, and 22q. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 12.8), testis (RPKM 12.2) and 25 other tissues See more
Orthologs
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Genomic context

See MRPS18C in Genome Data Viewer
Location:
4q21.23
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (83456058..83462298)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (84377211..84383451)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene chromosome 18 open reading frame 21 pseudogene Neighboring gene helicase, POLQ like Neighboring gene Sharpr-MPRA regulatory region 5990 Neighboring gene abraxas 1, BRCA1 A complex subunit Neighboring gene solute carrier family 25 member 14 pseudogene 1 Neighboring gene ribosomal protein L30 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11146, FLJ22967

Gene Ontology Provided by GOA

Function Evidence Code Pubs
small ribosomal subunit rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
28S ribosomal protein S18c, mitochondrial
Names
28S ribosomal protein S18-1, mitochondrial
mitochondrial ribosomal protein S18-1
mitochondrial small ribosomal subunit protein bS18c
mitochondrial small ribosomal subunit protein bS18m
mitochondrial small ribosomal subunit protein bS18m-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297767.2NP_001284696.1  28S ribosomal protein S18c, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001284696.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC096768, CN262115
    Consensus CDS
    CCDS75159.1
    UniProtKB/TrEMBL
    D6RCM2
    Related
    ENSP00000427169.1, ENST00000507019.5
    Conserved Domains (1) summary
    pfam01084
    Location:5092
    Ribosomal_S18; Ribosomal protein S18
  2. NM_001297769.2NP_001284698.1  28S ribosomal protein S18c, mitochondrial isoform 3

    See identical proteins and their annotated locations for NP_001284698.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the central coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus.
    Source sequence(s)
    AC096768, AF151892, BE874586, DA446717
    UniProtKB/Swiss-Prot
    Q9Y3D5
    Related
    ENSP00000425268.1, ENST00000505719.1
  3. NM_001297770.2NP_001284699.1  28S ribosomal protein S18c, mitochondrial isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two consecutive exons in the central coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC096768, AF151892, CA455563
    Consensus CDS
    CCDS77933.1
    UniProtKB/Swiss-Prot
    Q9Y3D5
    UniProtKB/TrEMBL
    D6RE70
    Related
    ENSP00000426930.1, ENST00000507349.5
  4. NM_016067.4NP_057151.1  28S ribosomal protein S18c, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_057151.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC096768, AF151892
    Consensus CDS
    CCDS3604.1
    UniProtKB/Swiss-Prot
    Q9Y3D5
    UniProtKB/TrEMBL
    A0A024RDH9
    Related
    ENSP00000295491.4, ENST00000295491.9
    Conserved Domains (1) summary
    pfam01084
    Location:70120
    Ribosomal_S18; Ribosomal protein S18

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    83456058..83462298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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