Format

Send to:

Choose Destination

WASHC3 WASH complex subunit 3 [ Homo sapiens (human) ]

Gene ID: 51019, updated on 29-Mar-2020

Summary

Official Symbol
WASHC3provided by HGNC
Official Full Name
WASH complex subunit 3provided by HGNC
Primary source
HGNC:HGNC:24256
See related
Ensembl:ENSG00000120860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCDC53; CGI-116
Expression
Broad expression in testis (RPKM 48.2), adrenal (RPKM 16.9) and 24 other tissues See more
Orthologs

Genomic context

See WASHC3 in Genome Data Viewer
Location:
12q23.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (102012840..102062124, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (102406717..102455902, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L9 pseudogene 24 Neighboring gene uncharacterized LOC107984548 Neighboring gene neudesin neurotrophic factor pseudogene 2 Neighboring gene nucleoporin 37 Neighboring gene PARP1 binding protein Neighboring gene pro-melanin concentrating hormone

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of coiled-coil domain containing 53 (CCDC53) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
biological_process ND
No biological Data available
more info
 
exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
WASH complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
WASH complex IDA
Inferred from Direct Assay
more info
PubMed 
early endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
WASH complex subunit 3
Names
WASH complex subunit CCDC53
coiled-coil domain containing 53
coiled-coil domain-containing protein 53

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301107.1NP_001288036.1  WASH complex subunit 3 isoform 2

    See identical proteins and their annotated locations for NP_001288036.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC079907, BX356987, DB452335
    Consensus CDS
    CCDS73512.1
    UniProtKB/TrEMBL
    F5GZ97
    Related
    ENSP00000443857.1, ENST00000545679.5
    Conserved Domains (1) summary
    pfam10152
    Location:30166
    DUF2360; Predicted coiled-coil domain-containing protein (DUF2360)
  2. NM_016053.4NP_057137.1  WASH complex subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_057137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC079907, AF151874
    Consensus CDS
    CCDS44959.1
    UniProtKB/Swiss-Prot
    Q9Y3C0
    Related
    ENSP00000240079.6, ENST00000240079.11
    Conserved Domains (1) summary
    pfam10152
    Location:30167
    DUF2360; Predicted coiled-coil domain-containing protein (DUF2360)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    102012840..102062124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448998.1XP_024304766.1  WASH complex subunit 3 isoform X3

    Conserved Domains (1) summary
    pfam10152
    Location:18133
    DUF2360; Predicted coiled-coil domain-containing protein (DUF2360)
  2. XM_017019383.1XP_016874872.1  WASH complex subunit 3 isoform X2

  3. XM_011538423.1XP_011536725.1  WASH complex subunit 3 isoform X1

    UniProtKB/TrEMBL
    F5GWI9
    Related
    ENSP00000441810.1, ENST00000540536.5
    Conserved Domains (1) summary
    pfam10152
    Location:30167
    DUF2360; Predicted coiled-coil domain-containing protein (DUF2360)
Support Center