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MED31 mediator complex subunit 31 [ Homo sapiens (human) ]

Gene ID: 51003, updated on 7-Jun-2020

Summary

Official Symbol
MED31provided by HGNC
Official Full Name
mediator complex subunit 31provided by HGNC
Primary source
HGNC:HGNC:24260
See related
Ensembl:ENSG00000108590
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Soh1; CGI-125; 3110004H13Rik
Expression
Ubiquitous expression in brain (RPKM 6.0), adrenal (RPKM 4.6) and 25 other tissues See more
Orthologs

Genomic context

See MED31 in Genome Data Viewer
Location:
17p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (6643311..6651605, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6546633..6555191, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene PICALM interacting mitotic regulator Neighboring gene PITPNM family member 3 Neighboring gene KIAA0753 Neighboring gene RNA, 5S ribosomal pseudogene 435 Neighboring gene thioredoxin domain containing 17 Neighboring gene chromosome 17 open reading frame 100 Neighboring gene microRNA 4520-1 Neighboring gene microRNA 4520-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 31 (MED31) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Knockdown of MED31 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27436, FLJ36714

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
limb development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 31
Names
hSOH1
mediator complex subunit SOH1
mediator of RNA polymerase II transcription, subunit 31 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016060.3NP_057144.1  mediator of RNA polymerase II transcription subunit 31

    See identical proteins and their annotated locations for NP_057144.1

    Status: VALIDATED

    Source sequence(s)
    AC004706, AF151883
    Consensus CDS
    CCDS11078.1
    UniProtKB/Swiss-Prot
    Q9Y3C7
    Related
    ENSP00000225728.3, ENST00000225728.8
    Conserved Domains (1) summary
    pfam05669
    Location:16108
    Med31; SOH1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    6643311..6651605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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