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PCBP2 poly(rC) binding protein 2 [ Homo sapiens (human) ]

Gene ID: 5094, updated on 3-Jan-2019

Summary

Official Symbol
PCBP2provided by HGNC
Official Full Name
poly(rC) binding protein 2provided by HGNC
Primary source
HGNC:HGNC:8648
See related
Ensembl:ENSG00000197111 MIM:601210
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNRPE2; HNRNPE2; hnRNP-E2
Summary
The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]
Expression
Ubiquitous expression in kidney (RPKM 155.8), thyroid (RPKM 127.6) and 25 other tissues See more
Orthologs

Genomic context

See PCBP2 in Genome Data Viewer
Location:
12q13.13
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (53452102..53481162)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53845886..53874946)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene anti-Mullerian hormone receptor type 2 Neighboring gene proline rich 13 Neighboring gene PCBP2 overlapping transcript 1 Neighboring gene mitogen-activated protein kinase kinase kinase 12 Neighboring gene TARBP2, RISC loading complex RNA binding subunit Neighboring gene neuropeptide FF-amide peptide precursor Neighboring gene activating transcription factor 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacts with the heterogeneous nuclear ribonucleoproteins (hnRNP) E2 PubMed
Tat tat Poly(rC) binding protein 2 (PCBP2) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Ferroptosis, organism-specific biosystem (from KEGG)
    Ferroptosis, organism-specific biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
  • Ferroptosis, conserved biosystem (from KEGG)
    Ferroptosis, conserved biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem (from REACTOME)
    Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystemAs with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
  • mRNA Processing, organism-specific biosystem (from WikiPathways)
    mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC110998

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C-rich single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
IRES-dependent viral translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
RNA metabolic process TAS
Traceable Author Statement
more info
 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
mRNA metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
negative regulation of defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of type I interferon production TAS
Traceable Author Statement
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral RNA genome replication IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
poly(rC)-binding protein 2
Names
alpha-CP2
epididymis secretory sperm binding protein
heterogeneous nuclear ribonucleoprotein E2
heterogenous nuclear ribonucleoprotein E2
hnRNP E2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098620.2NP_001092090.1  poly(rC)-binding protein 2 isoform c

    See identical proteins and their annotated locations for NP_001092090.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB188306, AC023509, AK130583, BF509278
    Consensus CDS
    CCDS44903.1
    UniProtKB/Swiss-Prot
    Q15366
    Related
    ENSP00000352228.5, ENST00000359282.9
    Conserved Domains (2) summary
    cd02396
    Location:99163
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:255318
    KH_1; KH domain
  2. NM_001128911.1NP_001122383.1  poly(rC)-binding protein 2 isoform d

    See identical proteins and their annotated locations for NP_001122383.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is one amino acid shorter compared to isoform a.
    Source sequence(s)
    AB188306, AC023509, AK130583, BF509278, X78136
    Consensus CDS
    CCDS44901.1
    UniProtKB/Swiss-Prot
    Q15366
    Related
    ENSP00000408949.2, ENST00000439930.7
    Conserved Domains (2) summary
    cd02396
    Location:99163
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:289352
    KH_1; KH domain
  3. NM_001128912.1NP_001122384.1  poly(rC)-binding protein 2 isoform e

    See identical proteins and their annotated locations for NP_001122384.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses two alternate in-frame splice sites compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is five amino acids shorter compared to isoform a.
    Source sequence(s)
    AB188306, AB208825, AC023509, AK130583, BF509278
    Consensus CDS
    CCDS55830.1
    UniProtKB/Swiss-Prot
    Q15366
    Related
    ENSP00000448927.2, ENST00000552296.6
    Conserved Domains (2) summary
    cd02396
    Location:99163
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:285348
    KH_1; KH domain
  4. NM_001128913.1NP_001122385.1  poly(rC)-binding protein 2 isoform f

    See identical proteins and their annotated locations for NP_001122385.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (f) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB188306, AC023509, AK130583, BC107688, BF509278
    Consensus CDS
    CCDS44902.1
    UniProtKB/Swiss-Prot
    Q15366
    Related
    ENSP00000394116.1, ENST00000447282.5
    Conserved Domains (2) summary
    cd02396
    Location:99163
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:259322
    KH_1; KH domain
  5. NM_001128914.1NP_001122386.1  poly(rC)-binding protein 2 isoform g

    See identical proteins and their annotated locations for NP_001122386.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice site and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (g) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB188306, AC023509, AK130583, AK225357, BF509278
    Consensus CDS
    CCDS44904.1
    UniProtKB/Swiss-Prot
    Q15366
    Related
    ENSP00000390304.1, ENST00000437231.5
    Conserved Domains (2) summary
    cd02396
    Location:99163
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:242305
    KH_1; KH domain
  6. NM_005016.5NP_005007.2  poly(rC)-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_005007.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB188306, AC023509, AK130583, BC035420, BF509278
    Consensus CDS
    CCDS44900.1
    UniProtKB/Swiss-Prot
    Q15366
    Related
    ENSP00000352438.5, ENST00000359462.9
    Conserved Domains (2) summary
    cd02396
    Location:99163
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:290353
    KH_1; KH domain
  7. NM_031989.4NP_114366.1  poly(rC)-binding protein 2 isoform b

    See identical proteins and their annotated locations for NP_114366.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB188306, AC023509, AK130583, AK292141, BF509278
    Consensus CDS
    CCDS8859.1
    UniProtKB/Swiss-Prot
    Q15366
    Related
    ENSP00000448762.1, ENST00000546463.5
    Conserved Domains (2) summary
    cd02396
    Location:99163
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:286349
    KH_1; KH domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    53452102..53481162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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