U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ACE2 angiotensin converting enzyme 2 [ Bos taurus (domestic cattle) ]

Gene ID: 509235, updated on 5-Sep-2025
Official Symbol
ACE2provided by VGNC
Official Full Name
angiotensin converting enzyme 2provided by VGNC
Primary source
VGNC:VGNC:25535
See related
BGD:BT28683; EnsemblRapid:ENSBTAG00070027456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
ACE-2
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See ACE2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (127902377..127953562)

Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101904527 Neighboring gene carbonic anhydrase 5B, mitochondrial-like Neighboring gene collectrin, amino acid transport regulator Neighboring gene uncharacterized LOC132344367 Neighboring gene iron-sulfur cluster assembly 1 homolog, mitochondrial-like Neighboring gene BMX non-receptor tyrosine kinase Neighboring gene transcription factor E2F6-like Neighboring gene pirin

Genomic Sequence:
NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Molecular characterization and regulation of the angiotensin-converting enzyme type 2/angiotensin-(1-7)/MAS receptor axis during the ovulation process in cattle. Tonellotto dos Santos J, et al. J Renin Angiotensin Aldosterone Syst, 2012 Mar. PMID 21824993
  2. Diversity of ACE2 and its interaction with SARS-CoV-2 receptor binding domain. Low-Gan J, et al. Biochem J, 2021 Oct 15. PMID 34558627
  3. Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin. Niu S, et al. EMBO J, 2021 Aug 16. PMID 34018203, Free PMC Article
  4. TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions. Xu J, et al. Theranostics, 2021. PMID 34158856, Free PMC Article
  5. Evolution of SARS-CoV-2 Spikes shapes their binding affinities to animal ACE2 orthologs. Yao W, et al. Microbiol Spectr, 2023 Dec 12. PMID 37943512, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The objective of this study was to characterize the profiles of Ang-(1-7), MAS receptor, ACE(2), NEP and PEP during the ovulatory process in cattle.
    Title: Molecular characterization and regulation of the angiotensin-converting enzyme type 2/angiotensin-(1-7)/MAS receptor axis during the ovulation process in cattle.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC127593

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptidyl-dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
angiotensin-converting enzyme 2
Names
ACE-related carboxypeptidase
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
angiotensin I converting enzyme 2
NP_001019673.2
XP_024843618.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024502.4 → NP_001019673.2  angiotensin-converting enzyme 2 precursor

    See identical proteins and their annotated locations for NP_001019673.2

    Status: VALIDATED

    Source sequence(s)
    BC105340, DT822597
    UniProtKB/Swiss-Prot
    Q58DD0
    UniProtKB/TrEMBL
    Q2HJI5
    Related
    ENSBTAP00070037328.1, ENSBTAT00070062471.1
    Conserved Domains (2) summary
    pfam01401
    Location:19 → 605
    Peptidase_M2; Angiotensin-converting enzyme
    pfam16959
    Location:616 → 769
    Collectrin; Renal amino acid transporter

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    127902377..127953562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024987850.2 → XP_024843618.1  angiotensin-converting enzyme 2 isoform X1

    UniProtKB/TrEMBL
    A0AAA9T867, A0AAA9TTY1
    Related
    ENSBTAP00070037341.1, ENSBTAT00070062486.1
    Conserved Domains (2) summary
    pfam01401
    Location:19 → 604
    Peptidase_M2; Angiotensin-converting enzyme
    pfam16959
    Location:616 → 769
    Collectrin; Renal amino acid transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q58DD0.1 GenPept UniProtKB/Swiss-Prot:Q58DD0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials