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Myadm myeloid-associated differentiation marker [ Mus musculus (house mouse) ]

Gene ID: 50918, updated on 12-May-2024

Summary

Official Symbol
Myadmprovided by MGI
Official Full Name
myeloid-associated differentiation markerprovided by MGI
Primary source
MGI:MGI:1355332
See related
Ensembl:ENSMUSG00000068566 AllianceGenome:MGI:1355332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D7Wsu62e
Summary
Predicted to be involved in several processes, including negative regulation of heterotypic cell-cell adhesion; negative regulation of macromolecule metabolic process; and negative regulation of protein kinase C signaling. Predicted to be located in cortical actin cytoskeleton; membrane raft; and ruffle. Predicted to be active in cell-cell junction and plasma membrane. Is expressed in several structures, including bone marrow; extraembryonic component; intestine smooth muscle circular layer; limb; and lung. Orthologous to human MYADM (myeloid associated differentiation marker). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 144.9), subcutaneous fat pad adult (RPKM 132.9) and 27 other tissues See more
Orthologs
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Genomic context

See Myadm in Genome Data Viewer
Location:
7 A1; 7 1.92 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3337563..3347871)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3289038..3299355)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17893 Neighboring gene olfactory receptor GA_x5J8B7W3939-136239-135295 Neighboring gene STARR-positive B cell enhancer ABC_E10422 Neighboring gene acidic ribosomal phosphoprotein P0 pseudogene Neighboring gene protein kinase C, gamma Neighboring gene STARR-seq mESC enhancer starr_17899 Neighboring gene calcium channel, voltage-dependent, gamma subunit 7 Neighboring gene STARR-seq mESC enhancer starr_17900

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation
  • Transposon induced (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myeloid-associated differentiation marker
Names
myeloid up-regulated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093764.1NP_001087233.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001087233.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI842980, AK052258, BY163724, CJ156102, CK782239
    Consensus CDS
    CCDS51964.1
    UniProtKB/Swiss-Prot
    O35682, Q8BGS9, Q8BPS8
    UniProtKB/TrEMBL
    Q0VE46
    Related
    ENSMUSP00000144984.2, ENSMUST00000203328.4
    Conserved Domains (1) summary
    pfam01284
    Location:39146
    MARVEL; Membrane-associating domain
  2. NM_001093765.1NP_001087234.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001087234.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI842980, AK052258, BY252968, BY767460
    Consensus CDS
    CCDS51964.1
    UniProtKB/Swiss-Prot
    O35682, Q8BGS9, Q8BPS8
    UniProtKB/TrEMBL
    Q0VE46
    Related
    ENSMUSP00000145120.2, ENSMUST00000203566.3
    Conserved Domains (1) summary
    pfam01284
    Location:39146
    MARVEL; Membrane-associating domain
  3. NM_001093766.1NP_001087235.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001087235.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI842980, AK052258, CF166357
    Consensus CDS
    CCDS51964.1
    UniProtKB/Swiss-Prot
    O35682, Q8BGS9, Q8BPS8
    UniProtKB/TrEMBL
    Q0VE46
    Related
    ENSMUSP00000131318.2, ENSMUST00000164553.8
    Conserved Domains (1) summary
    pfam01284
    Location:39146
    MARVEL; Membrane-associating domain
  4. NM_016969.2NP_058665.2  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_058665.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI842980, AK052258, AK089538, BY060170
    Consensus CDS
    CCDS51964.1
    UniProtKB/Swiss-Prot
    O35682, Q8BGS9, Q8BPS8
    UniProtKB/TrEMBL
    Q0VE46
    Related
    ENSMUSP00000094505.6, ENSMUST00000096744.8
    Conserved Domains (1) summary
    pfam01284
    Location:39146
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3337563..3347871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540171.5XP_006540234.1  myeloid-associated differentiation marker isoform X1

    See identical proteins and their annotated locations for XP_006540234.1

    UniProtKB/Swiss-Prot
    O35682, Q8BGS9, Q8BPS8
    UniProtKB/TrEMBL
    Q0VE46
    Conserved Domains (1) summary
    pfam01284
    Location:39146
    MARVEL; Membrane-associating domain