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Galns galactosamine (N-acetyl)-6-sulfate sulfatase [ Mus musculus (house mouse) ]

Gene ID: 50917, updated on 24-Jun-2022

Summary

Official Symbol
Galnsprovided by MGI
Official Full Name
galactosamine (N-acetyl)-6-sulfate sulfataseprovided by MGI
Primary source
MGI:MGI:1355303
See related
Ensembl:ENSMUSG00000015027 AllianceGenome:MGI:1355303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mFLJ00319
Summary
Predicted to enable arylsulfatase activity. Predicted to be located in lysosome. Is expressed in embryo; lens epithelium; neural retina; and retina. Used to study mucopolysaccharidosis IV. Human ortholog(s) of this gene implicated in mucopolysaccharidosis IVA. Orthologous to human GALNS (galactosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 15.5), kidney adult (RPKM 12.0) and 28 other tissues See more
Orthologs
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Genomic context

See Galns in Genome Data Viewer
Location:
8; 8 E1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123304976..123338226, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122578237..122611701, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (125102137..125135241, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene chromatin licensing and DNA replication factor 1 Neighboring gene adenine phosphoribosyl transferase Neighboring gene predicted gene, 34962 Neighboring gene 60S ribosomal protein L30 pseudogene Neighboring gene trafficking protein particle complex 2L Neighboring gene poly(A)binding protein nuclear 1-like Neighboring gene microRNA 6396

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ00319

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylgalactosamine-6-sulfatase activity IEA
Inferred from Electronic Annotation
more info
 
enables N-acetylgalactosamine-6-sulfatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables arylsulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables sulfuric ester hydrolase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in chondroitin sulfate catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in lysosome IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
N-acetylgalactosamine-6-sulfatase
Names
GalNAc6S sulfatase
N-acetylgalactosamine-6-sulfate sulfatase
chondroitinase
chondroitinsulfatase
galactose-6-sulfate sulfatase
NP_001180574.1
NP_057931.3
XP_006531240.1
XP_017168383.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193645.1NP_001180574.1  N-acetylgalactosamine-6-sulfatase isoform 2 precursor

    See identical proteins and their annotated locations for NP_001180574.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC151999, AI504634, AK033946, AK159592, BY348800
    Consensus CDS
    CCDS85625.1
    UniProtKB/Swiss-Prot
    Q571E4
    UniProtKB/TrEMBL
    Q8CC47
    Related
    ENSMUSP00000148591.2, ENSMUST00000212319.2
    Conserved Domains (2) summary
    COG3119
    Location:28335
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cl23718
    Location:27412
    ALP_like; alkaline phosphatases and sulfatases
  2. NM_016722.4NP_057931.3  N-acetylgalactosamine-6-sulfatase isoform 1 precursor

    See identical proteins and their annotated locations for NP_057931.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI504634, AK159592, BY348800
    Consensus CDS
    CCDS40504.1
    UniProtKB/Swiss-Prot
    Q571E4
    Related
    ENSMUSP00000015171.10, ENSMUST00000015171.11
    Conserved Domains (2) summary
    PRK13759
    Location:28473
    PRK13759; arylsulfatase; Provisional
    cd16157
    Location:27492
    GALNS; galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123304976..123338226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312894.2XP_017168383.1  N-acetylgalactosamine-6-sulfatase isoform X1

    Conserved Domains (1) summary
    cl23718
    Location:1382
    ALP_like; alkaline phosphatases and sulfatases
  2. XM_006531177.3XP_006531240.1  N-acetylgalactosamine-6-sulfatase isoform X2

    Conserved Domains (1) summary
    cl23718
    Location:27332
    ALP_like; alkaline phosphatases and sulfatases

RNA

  1. XR_387755.3 RNA Sequence

  2. XR_387756.4 RNA Sequence