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Exosc10 exosome component 10 [ Mus musculus (house mouse) ]

Gene ID: 50912, updated on 6-Jun-2024

Summary

Official Symbol
Exosc10provided by MGI
Official Full Name
exosome component 10provided by MGI
Primary source
MGI:MGI:1355322
See related
Ensembl:ENSMUSG00000017264 AllianceGenome:MGI:1355322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p2; p3; p4; RRP6; PM-Scl; Pmscl2; PM/Scl-100
Summary
Predicted to enable 3'-5'-exoribonuclease activity and single-stranded RNA binding activity. Acts upstream of or within dosage compensation by inactivation of X chromosome. Predicted to be located in cytosol; nucleoplasm; and transcriptionally active chromatin. Predicted to be part of nuclear exosome (RNase complex). Predicted to be active in nucleolus. Orthologous to human EXOSC10 (exosome component 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 12.4), CNS E14 (RPKM 12.3) and 28 other tissues See more
Orthologs
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Genomic context

See Exosc10 in Genome Data Viewer
Location:
4 E2; 4 78.76 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148642870..148666854)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148558419..148582401)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene mechanistic target of rapamycin kinase Neighboring gene predicted gene, 24002 Neighboring gene STARR-positive B cell enhancer ABC_E1668 Neighboring gene predicted gene, 23318 Neighboring gene MBL associated serine protease 2 Neighboring gene spermidine synthase Neighboring gene TAR DNA binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in CUT catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in TRAMP-dependent tRNA surveillance pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in histone mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in histone mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in maturation of 5.8S rRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear mRNA surveillance ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear polyadenylation-dependent CUT catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear polyadenylation-dependent antisense transcript catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear polyadenylation-dependent rRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear polyadenylation-dependent snRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear polyadenylation-dependent snoRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear-transcribed mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in poly(A)-dependent snoRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of mRNA cis splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of telomerase RNA localization to Cajal body ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of cytoplasmic exosome (RNase complex) NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
 
part_of exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear exosome (RNase complex) NAS
Non-traceable Author Statement
more info
PubMed 
part_of nucleolar exosome (RNase complex) NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus TAS
Traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
exosome complex component 10
Names
P100 polymyositis-scleroderma overlap syndrome associated autoantigen homolog
autoantigen PM/Scl 2 homolog
polymyositis/scleroderma autoantigen 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355489.2NP_001342418.1  exosome complex component 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606969, AL713995
    UniProtKB/TrEMBL
    Q3UNK6
    Conserved Domains (3) summary
    cd06147
    Location:202391
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:420500
    HRDC; Helicase and RNase D C-terminal
    pfam08066
    Location:147
    PMC2NT; PMC2NT (NUC016) domain
  2. NM_001355490.2NP_001342419.1  exosome complex component 10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606969, AL713995
    Consensus CDS
    CCDS89857.1
    UniProtKB/TrEMBL
    Q3UNK6, Q8K366
    Related
    ENSMUSP00000075401.7, ENSMUST00000076022.7
    Conserved Domains (3) summary
    cd06147
    Location:285474
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:503583
    HRDC; Helicase and RNase D C-terminal
    pfam08066
    Location:46130
    PMC2NT; PMC2NT (NUC016) domain
  3. NM_001424999.1NP_001411928.1  exosome complex component 10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL606969, AL713995
    UniProtKB/TrEMBL
    Q3UNK6
  4. NM_001425000.1NP_001411929.1  exosome complex component 10 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL606969, AL713995
    UniProtKB/TrEMBL
    Q3UNK6
  5. NM_001425001.1NP_001411930.1  exosome complex component 10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL606969, AL713995
    UniProtKB/TrEMBL
    Q3UNK6
  6. NM_016699.4NP_057908.2  exosome complex component 10 isoform 1

    See identical proteins and their annotated locations for NP_057908.2

    Status: VALIDATED

    Source sequence(s)
    AL606969, AL713995
    Consensus CDS
    CCDS18939.1
    UniProtKB/Swiss-Prot
    B1ARY9, P56960, Q9QYS8, Q9R0B1
    UniProtKB/TrEMBL
    Q3UNK6
    Related
    ENSMUSP00000017408.8, ENSMUST00000017408.14
    Conserved Domains (3) summary
    cd06147
    Location:285474
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:503583
    HRDC; Helicase and RNase D C-terminal
    pfam08066
    Location:46132
    PMC2NT; PMC2NT (NUC016) domain

RNA

  1. NR_131061.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606969, AL713995
    Related
    ENSMUST00000097781.11
  2. NR_189026.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606969, AL713995
    Related
    ENSMUST00000173154.8
  3. NR_189027.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606969, AL713995

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    148642870..148666854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539023.5XP_006539086.1  exosome complex component 10 isoform X1

    UniProtKB/TrEMBL
    Q3UNK6
    Conserved Domains (3) summary
    cd06147
    Location:285474
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:503583
    HRDC; Helicase and RNase D C-terminal
    pfam08066
    Location:46133
    PMC2NT; PMC2NT (NUC016) domain
  2. XM_006539024.3XP_006539087.1  exosome complex component 10 isoform X2

    UniProtKB/TrEMBL
    Q3UNK6
    Conserved Domains (3) summary
    cd06147
    Location:202391
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:420500
    HRDC; Helicase and RNase D C-terminal
    pfam08066
    Location:150
    PMC2NT; PMC2NT (NUC016) domain
  3. XM_011250300.4XP_011248602.1  exosome complex component 10 isoform X3

    Conserved Domains (2) summary
    cd06147
    Location:59248
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:277357
    HRDC; Helicase and RNase D C-terminal

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_131062.2: Suppressed sequence

    Description
    NR_131062.2: This RefSeq was removed because currently there is insufficient support for the transcript.