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Exosc10 exosome component 10 [ Mus musculus (house mouse) ]

Gene ID: 50912, updated on 26-Mar-2023

Summary

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Official Symbol
Exosc10provided by MGI
Official Full Name
exosome component 10provided by MGI
Primary source
MGI:MGI:1355322
See related
Ensembl:ENSMUSG00000017264 AllianceGenome:MGI:1355322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p2; p3; p4; RRP6; PM-Scl; Pmscl2; PM/Scl-100
Summary
Predicted to enable 3'-5'-exoribonuclease activity and single-stranded RNA binding activity. Acts upstream of or within dosage compensation by inactivation of X chromosome. Predicted to be located in cytosol; nucleoplasm; and transcriptionally active chromatin. Predicted to be part of nuclear exosome (RNase complex). Predicted to be active in nucleolus. Orthologous to human EXOSC10 (exosome component 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 12.4), CNS E14 (RPKM 12.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Exosc10 in Genome Data Viewer
Location:
4; 4 E2
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148642870..148666858)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148558419..148582401)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene mechanistic target of rapamycin kinase Neighboring gene predicted gene, 24002 Neighboring gene predicted gene, 23318 Neighboring gene mannan-binding lectin serine peptidase 2 Neighboring gene spermidine synthase Neighboring gene TAR DNA binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inactivation of Exosc10 in the oocyte impairs oocyte development and maturation, leading to a depletion of the ovarian reserve in mice. Demini L, et al. Int J Biol Sci, 2023. PMID 36923944, Free PMC Article
  2. EXOSC10 sculpts the transcriptome during the growth-to-maturation transition in mouse oocytes. Wu D, et al. Nucleic Acids Res, 2020 Jun 4. PMID 32313933, Free PMC Article
  3. EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis. Jamin SP, et al. Sci Rep, 2017 Nov 8. PMID 29118343, Free PMC Article
  4. RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity. Pefanis E, et al. Cell, 2015 May 7. PMID 25957685, Free PMC Article
  5. EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transition. Petit FG, et al. Dev Biol, 2022 Mar. PMID 34965385

See all (35) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inactivation of Exosc10 in the oocyte impairs oocyte development and maturation, leading to a depletion of the ovarian reserve in mice.
    Title: Inactivation of Exosc10 in the oocyte impairs oocyte development and maturation, leading to a depletion of the ovarian reserve in mice.
  2. EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transition.
    Title: EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transition.
  3. EXOSC10 promotes normal growth-to-maturation transition in mouse oocytes by sculpting the transcriptome to degrade RNAs encoding growth-phase factors and, thus, support the maturation phase of oogenesis.
    Title: EXOSC10 sculpts the transcriptome during the growth-to-maturation transition in mouse oocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in CUT catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dosage compensation by inactivation of X chromosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in histone mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in histone mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in maturation of 5.8S rRNA ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear mRNA surveillance ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear polyadenylation-dependent CUT catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in nuclear polyadenylation-dependent antisense transcript catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in nuclear polyadenylation-dependent rRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear polyadenylation-dependent snRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in nuclear polyadenylation-dependent snoRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in nuclear polyadenylation-dependent tRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in polyadenylation-dependent snoRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of telomerase RNA localization to Cajal body ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of cytoplasmic exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in euchromatin ISO
Inferred from Sequence Orthology
more info
  
part_of exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of nuclear exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
part_of nucleolar exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
exosome component 10
Names
P100 polymyositis-scleroderma overlap syndrome associated autoantigen homolog
autoantigen PM/Scl 2 homolog
polymyositis/scleroderma autoantigen 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355489.1 → NP_001342418.1  exosome component 10 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AA920441, AK081014, AL713995, AW494502, BY294057, CA749889, CF172035, CX205723, DV652107, DV659796
    Conserved Domains (3) summary
    cd06147
    Location:202 → 391
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:420 → 500
    HRDC; Helicase and RNase D C-terminal
    pfam08066
    Location:1 → 47
    PMC2NT; PMC2NT (NUC016) domain

  2. NM_001355490.1 → NP_001342419.1  exosome component 10 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (3) has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AK162887, AK168700, AW494502, BY277385
    Consensus CDS
    CCDS89857.1
    UniProtKB/TrEMBL
    Q8K366
    Related
    ENSMUSP00000075401.7, ENSMUST00000076022.7
    Conserved Domains (3) summary
    cd06147
    Location:285 → 474
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:503 → 583
    HRDC; Helicase and RNase D C-terminal
    pfam08066
    Location:46 → 130
    PMC2NT; PMC2NT (NUC016) domain

  3. NM_016699.3 → NP_057908.2  exosome component 10 isoform 1

    See identical proteins and their annotated locations for NP_057908.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK081014, AK162887, AK168700, AW494502, BY277385
    Consensus CDS
    CCDS18939.1
    UniProtKB/Swiss-Prot
    P56960, Q9R0B1
    Related
    ENSMUSP00000017408.8, ENSMUST00000017408.14
    Conserved Domains (3) summary
    cd06147
    Location:285 → 474
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:503 → 583
    HRDC; Helicase and RNase D C-terminal
    pfam08066
    Location:46 → 132
    PMC2NT; PMC2NT (NUC016) domain

RNA

  1. NR_131061.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK168700, AW494502, BY277385
    Related
    ENSMUST00000097781.11

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    148642870..148666858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539023.5 → XP_006539086.1  exosome component 10 isoform X1

    Conserved Domains (3) summary
    cd06147
    Location:285 → 474
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:503 → 583
    HRDC; Helicase and RNase D C-terminal
    pfam08066
    Location:46 → 133
    PMC2NT; PMC2NT (NUC016) domain

  2. XM_006539024.3 → XP_006539087.1  exosome component 10 isoform X2

    Conserved Domains (3) summary
    cd06147
    Location:202 → 391
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:420 → 500
    HRDC; Helicase and RNase D C-terminal
    pfam08066
    Location:1 → 50
    PMC2NT; PMC2NT (NUC016) domain

  3. XM_011250300.4 → XP_011248602.1  exosome component 10 isoform X3

    Conserved Domains (2) summary
    cd06147
    Location:59 → 248
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:277 → 357
    HRDC; Helicase and RNase D C-terminal

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_131062.2: Suppressed sequence

    Description
    NR_131062.2: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56960.2 GenPept UniProtKB/Swiss-Prot:P56960

Gene LinkOut

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