Exosc10 exosome component 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Exosc10provided by MGI
Official Full Name: exosome component 10provided by MGI
Primary source: MGI:MGI:1355322
See related: Ensembl:ENSMUSG00000017264 AllianceGenome:MGI:1355322
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p2; p3; p4; RRP6; PM-Scl; Pmscl2; PM/Scl-100
Summary: Predicted to enable 3'-5'-RNA exonuclease activity; single-stranded RNA binding activity; and telomerase RNA binding activity. Acts upstream of or within positive regulation of mRNA cis splicing, via spliceosome and random inactivation of X chromosome. Predicted to be located in cytosol; euchromatin; and nucleoplasm. Predicted to be part of nuclear exosome (RNase complex) and small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including cerebral cortex; gonad; liver; metanephros; and muscle tissue. Orthologous to human EXOSC10 (exosome component 10). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in limb E14.5 (RPKM 12.4), CNS E14 (RPKM 12.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 78.76 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (148642870..148666854)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (148558419..148582401)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inactivation of Exosc10 in the oocyte impairs oocyte development and maturation, leading to a depletion of the ovarian reserve in mice.
Title: Inactivation of Exosc10 in the oocyte impairs oocyte development and maturation, leading to a depletion of the ovarian reserve in mice.
EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transition.
Title: EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transition.
EXOSC10 promotes normal growth-to-maturation transition in mouse oocytes by sculpting the transcriptome to degrade RNAs encoding growth-phase factors and, thus, support the maturation phase of oogenesis.
Title: EXOSC10 sculpts the transcriptome during the growth-to-maturation transition in mouse oocytes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235094

RH134710 (e-PCR)
- UniSTS:217988

AI327068 (e-PCR)
- UniSTS:179103

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5'-RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5'-RNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5'-RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomerase RNA binding	IEA Inferred from Electronic Annotation more info
enables telomerase RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CUT catabolic process	IEA Inferred from Electronic Annotation more info
involved_in CUT catabolic process	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in RNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in RNA processing	ISO Inferred from Sequence Orthology more info
involved_in TRAMP-dependent tRNA surveillance pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA Inferred from Electronic Annotation more info
involved_in histone mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in histone mRNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in histone mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in histone mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in maturation of 5.8S rRNA	IEA Inferred from Electronic Annotation more info
involved_in maturation of 5.8S rRNA	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in nuclear mRNA surveillance	IEA Inferred from Electronic Annotation more info
involved_in nuclear mRNA surveillance	ISO Inferred from Sequence Orthology more info
involved_in nuclear polyadenylation-dependent CUT catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear polyadenylation-dependent antisense transcript catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear polyadenylation-dependent rRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear polyadenylation-dependent rRNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in nuclear polyadenylation-dependent rRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nuclear polyadenylation-dependent snRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear polyadenylation-dependent snoRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in poly(A)-dependent snoRNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of mRNA cis splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within random inactivation of X chromosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in regulation of nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of telomerase RNA localization to Cajal body	IEA Inferred from Electronic Annotation more info
involved_in regulation of telomerase RNA localization to Cajal body	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	IEA Inferred from Electronic Annotation more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of cytoplasmic exosome (RNase complex)	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in euchromatin	IEA Inferred from Electronic Annotation more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
part_of exosome (RNase complex)	IEA Inferred from Electronic Annotation more info
part_of exosome (RNase complex)	ISO Inferred from Sequence Orthology more info
part_of exosome (RNase complex)	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear exosome (RNase complex)	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear exosome (RNase complex)	IEA Inferred from Electronic Annotation more info
part_of nuclear exosome (RNase complex)	ISO Inferred from Sequence Orthology more info
part_of nuclear exosome (RNase complex)	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear exosome (RNase complex)	NAS Non-traceable Author Statement more info	PubMed
part_of nucleolar exosome (RNase complex)	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	TAS Traceable Author Statement more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: exosome complex component 10

Names: P100 polymyositis-scleroderma overlap syndrome associated autoantigen homolog; autoantigen PM/Scl 2 homolog; polymyositis/scleroderma autoantigen 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355489.2 → NP_001342418.1 exosome complex component 10 isoform 2

Status: VALIDATED

Source sequence(s)

AL606969, AL713995

UniProtKB/TrEMBL

Q3UNK6

Conserved Domains (3) summary

cd06147
Location:202 → 391

Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins

smart00341
Location:420 → 500

HRDC; Helicase and RNase D C-terminal

pfam08066
Location:1 → 47

PMC2NT; PMC2NT (NUC016) domain
NM_001355490.2 → NP_001342419.1 exosome complex component 10 isoform 3

Status: VALIDATED

Source sequence(s)

AL606969, AL713995

Consensus CDS

CCDS89857.1

UniProtKB/TrEMBL

Q3UNK6, Q8K366

Related

ENSMUSP00000075401.7, ENSMUST00000076022.7

Conserved Domains (3) summary

cd06147
Location:285 → 474

Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins

smart00341
Location:503 → 583

HRDC; Helicase and RNase D C-terminal

pfam08066
Location:46 → 130

PMC2NT; PMC2NT (NUC016) domain
NM_001424999.1 → NP_001411928.1 exosome complex component 10 isoform 4

Status: VALIDATED

Source sequence(s)

AL606969, AL713995

UniProtKB/TrEMBL

Q3UNK6
NM_001425000.1 → NP_001411929.1 exosome complex component 10 isoform 6

Status: VALIDATED

Source sequence(s)

AL606969, AL713995

UniProtKB/TrEMBL

Q3UNK6
NM_001425001.1 → NP_001411930.1 exosome complex component 10 isoform 5

Status: VALIDATED

Source sequence(s)

AL606969, AL713995

UniProtKB/TrEMBL

Q3UNK6
NM_016699.4 → NP_057908.2 exosome complex component 10 isoform 1

See identical proteins and their annotated locations for NP_057908.2

Status: VALIDATED

Source sequence(s)

AL606969, AL713995

Consensus CDS

CCDS18939.1

UniProtKB/Swiss-Prot

B1ARY9, P56960, Q9QYS8, Q9R0B1

UniProtKB/TrEMBL

Q3UNK6

Related

ENSMUSP00000017408.8, ENSMUST00000017408.14

Conserved Domains (3) summary

cd06147
Location:285 → 474

Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins

smart00341
Location:503 → 583

HRDC; Helicase and RNase D C-terminal

pfam08066
Location:46 → 132

PMC2NT; PMC2NT (NUC016) domain

RNA

NR_131061.3 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL606969, AL713995

Related

ENSMUST00000097781.11
NR_189026.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL606969, AL713995

Related

ENSMUST00000173154.8
NR_189027.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL606969, AL713995

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

148642870..148666854

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539023.5 → XP_006539086.1 exosome complex component 10 isoform X1

UniProtKB/TrEMBL

Q3UNK6

Conserved Domains (3) summary

cd06147
Location:285 → 474

Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins

smart00341
Location:503 → 583

HRDC; Helicase and RNase D C-terminal

pfam08066
Location:46 → 133

PMC2NT; PMC2NT (NUC016) domain
XM_006539024.3 → XP_006539087.1 exosome complex component 10 isoform X2

UniProtKB/TrEMBL

Q3UNK6

Conserved Domains (3) summary

cd06147
Location:202 → 391

Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins

smart00341
Location:420 → 500

HRDC; Helicase and RNase D C-terminal

pfam08066
Location:1 → 50

PMC2NT; PMC2NT (NUC016) domain
XM_011250300.4 → XP_011248602.1 exosome complex component 10 isoform X3

Conserved Domains (2) summary

cd06147
Location:59 → 248

Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins

smart00341
Location:277 → 357

HRDC; Helicase and RNase D C-terminal

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NR_131062.2: Suppressed sequence

Description

NR_131062.2: This RefSeq was removed because currently there is insufficient support for the transcript.