U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

C1s1 complement component 1, s subcomponent 1 [ Mus musculus (house mouse) ]

Gene ID: 50908, updated on 24-Jan-2023

Summary

Official Symbol
C1s1provided by MGI
Official Full Name
complement component 1, s subcomponent 1provided by MGI
Primary source
MGI:MGI:1355312
See related
Ensembl:ENSMUSG00000038521 AllianceGenome:MGI:1355312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C1s; C1sa
Summary
Predicted to enable identical protein binding activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within complement activation, classical pathway and innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in chondrocranium; liver lobe; renal calyx; and urogenital ridge. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome periodontal type 2. Orthologous to human C1S (complement C1s). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 97.2), liver E18 (RPKM 57.1) and 14 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See C1s1 in Genome Data Viewer
Location:
6; 6 F2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124507303..124519340, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124530344..124542392, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 44096 Neighboring gene complement component 1, r subcomponent-like Neighboring gene complement component 1, r subcomponent A Neighboring gene complement component 1, r subcomponent A pseudogene Neighboring gene complement component 1, r subcomponent B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC37773, MGC132830

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in complement activation, classical pathway NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of complement component C1 complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
complement C1s-1 subcomponent; complement C1s-A subcomponent
Names
C1 esterase
complement component 1 subcomponent s-A
complement component C1SA
serine protease
NP_001091086.1
NP_659187.2
XP_006506428.1
XP_011239706.1
XP_011239707.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097617.1NP_001091086.1  complement C1s-1 subcomponent precursor

    See identical proteins and their annotated locations for NP_001091086.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK087522, BB805732, BC111880, BY144429
    Consensus CDS
    CCDS51907.1
    UniProtKB/Swiss-Prot
    Q8CG14
    UniProtKB/TrEMBL
    E9Q6C2, Q14DT6
    Related
    ENSMUSP00000125712.2, ENSMUST00000162443.8
    Conserved Domains (5) summary
    cd00033
    Location:307361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443681
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:181293
    CUB; CUB domain
    pfam14670
    Location:149177
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  2. NM_144938.2NP_659187.2  complement C1s-1 subcomponent precursor

    See identical proteins and their annotated locations for NP_659187.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK087522, BB805732, BC111880, BY110216
    Consensus CDS
    CCDS51907.1
    UniProtKB/Swiss-Prot
    Q8CG14
    UniProtKB/TrEMBL
    E9Q6C2, Q14DT6
    Related
    ENSMUSP00000125531.2, ENSMUST00000160505.8
    Conserved Domains (5) summary
    cd00033
    Location:307361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443681
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:181293
    CUB; CUB domain
    pfam14670
    Location:149177
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    124507303..124519340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241405.3XP_011239707.1  complement C1s-A subcomponent isoform X2

    Conserved Domains (5) summary
    cd00033
    Location:283337
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:419657
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:2111
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:157269
    CUB; CUB domain
    pfam14670
    Location:125153
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  2. XM_006506365.5XP_006506428.1  complement C1s-A subcomponent isoform X1

    See identical proteins and their annotated locations for XP_006506428.1

    UniProtKB/TrEMBL
    E9Q6C2
    Conserved Domains (5) summary
    cd00033
    Location:307361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443681
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:181293
    CUB; CUB domain
    pfam14670
    Location:149177
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  3. XM_011241404.4XP_011239706.1  complement C1s-A subcomponent isoform X1

    See identical proteins and their annotated locations for XP_011239706.1

    UniProtKB/TrEMBL
    E9Q6C2
    Conserved Domains (5) summary
    cd00033
    Location:307361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443681
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:181293
    CUB; CUB domain
    pfam14670
    Location:149177
    FXa_inhibition; Coagulation Factor Xa inhibitory site