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LCK LCK proto-oncogene, Src family tyrosine kinase [ Bos taurus (domestic cattle) ]

Gene ID: 508890, updated on 5-Sep-2025
Official Symbol
LCKprovided by VGNC
Official Full Name
LCK proto-oncogene, Src family tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:30810
See related
BGD:BT11613; EnsemblRapid:ENSBTAG00070009539
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See LCK in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (121262592..121283528, complement)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene MARCKS like 1 Neighboring gene histone deacetylase 1 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene family with sequence similarity 167 member B Neighboring gene myotubularin related protein 9-like

Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Constitutive activation of Lck and Fyn tyrosine kinases in large granular lymphocytes infected with the gamma-herpesvirus agents of malignant catarrhal fever. Swa S, et al. Immunology, 2001 Jan. PMID 11168636, Free PMC Article
  2. Partial purification and characterization of the lck protein-tyrosine kinase from bovine thymus. Wang QM, et al. Biochem J, 1991 Oct 15. PMID 1953650, Free PMC Article
  3. Identification of tyrosine 67 in bovine brain myelin basic protein as a specific phosphorylation site for thymus p56lck. Wang Q, et al. Biochem Biophys Res Commun, 1991 Aug 15. PMID 1714722
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC126900

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
tyrosine-protein kinase Lck
Names
Src family tyrosine kinase
lymphocyte-specific protein tyrosine kinase
NP_001029506.1
XP_010800705.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034334.1 → NP_001029506.1  tyrosine-protein kinase Lck

    See identical proteins and their annotated locations for NP_001029506.1

    Status: PROVISIONAL

    Source sequence(s)
    BC102046
    UniProtKB/TrEMBL
    F6QXU6, Q3ZCM0
    Related
    ENSBTAP00070012549.1, ENSBTAT00070021437.1
    Conserved Domains (3) summary
    cd10362
    Location:123 → 223
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:65 → 118
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:237 → 500
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    121262592..121283528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010802403.4 → XP_010800705.1  tyrosine-protein kinase Lck isoform X1

    UniProtKB/TrEMBL
    F6QXU6
    Conserved Domains (4) summary
    cd10362
    Location:86 → 186
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:28 → 81
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:200 → 463
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
    pfam07714
    Location:208 → 457
    Pkinase_Tyr; Protein tyrosine kinase
Nucleotide Protein Strain
Heading Accession and Version

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