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CIITA class II major histocompatibility complex transactivator [ Bos taurus (domestic cattle) ]

Gene ID: 508720, updated on 30-Jan-2025
Official Symbol
CIITAprovided by VGNC
Official Full Name
class II major histocompatibility complex transactivatorprovided by VGNC
Primary source
VGNC:VGNC:27366
See related
EnsemblRapid:ENSBTAG00070026568
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See CIITA in Genome Data Viewer
Location:
chromosome: 25
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (9542385..9601549)

Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene NUBP iron-sulfur cluster assembly factor 1, cytosolic Neighboring gene trans-golgi network vesicle protein 23 homolog A Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene C-type lectin domain containing 16A Neighboring gene Dexi homolog Neighboring gene uncharacterized LOC101907141

Genomic Sequence:
NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of MHC class I biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MHC class II biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
MHC class II transactivator
XP_010817557.1
XP_010817558.1
XP_010817559.1
XP_010817560.1
XP_024841195.1

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    9542385..9601549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010819255.4 → XP_010817557.1  MHC class II transactivator isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M5S3, F1MG35
    Related
    ENSBTAP00070035717.1, ENSBTAT00070060197.1
    Conserved Domains (5) summary
    cd00116
    Location:865 → 1190
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:1062 → 1092
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:490 → 661
    NACHT; NACHT domain
    pfam13855
    Location:1093 → 1160
    LRR_8; Leucine rich repeat
    pfam15730
    Location:313 → 389
    DUF4680; Domain of unknown function (DUF4680)

  2. XM_010819256.4 → XP_010817558.1  MHC class II transactivator isoform X2

    UniProtKB/TrEMBL
    A0A3Q1ME12
    Conserved Domains (4) summary
    cd00116
    Location:865 → 1128
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:1062 → 1092
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:490 → 661
    NACHT; NACHT domain
    pfam15730
    Location:313 → 389
    DUF4680; Domain of unknown function (DUF4680)

  3. XM_024985427.2 → XP_024841195.1  MHC class II transactivator isoform X5

    UniProtKB/TrEMBL
    A0A3Q1LZW6
    Conserved Domains (4) summary
    pfam05729
    Location:490 → 661
    NACHT; NACHT domain
    pfam05956
    Location:334 → 456
    APC_basic; APC basic domain
    pfam15279
    Location:253 → 369
    SOBP; Sine oculis-binding protein
    cl26161
    Location:865 → 961
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  4. XM_010819257.4 → XP_010817559.1  MHC class II transactivator isoform X3

    See identical proteins and their annotated locations for XP_010817559.1

    UniProtKB/TrEMBL
    A0A3Q1LQ73, A0A3Q1M5S3
    Related
    ENSBTAP00070035710.1, ENSBTAT00070060182.1
    Conserved Domains (5) summary
    cd00116
    Location:788 → 1113
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:985 → 1015
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:413 → 584
    NACHT; NACHT domain
    pfam13855
    Location:1016 → 1083
    LRR_8; Leucine rich repeat
    pfam15730
    Location:236 → 312
    DUF4680; Domain of unknown function (DUF4680)

  5. XM_010819258.4 → XP_010817560.1  MHC class II transactivator isoform X4

    See identical proteins and their annotated locations for XP_010817560.1

    UniProtKB/TrEMBL
    A0A3Q1M5S3
    Related
    ENSBTAP00070035703.1, ENSBTAT00070060169.1
    Conserved Domains (5) summary
    cd00116
    Location:773 → 1098
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:970 → 1000
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:398 → 569
    NACHT; NACHT domain
    pfam13855
    Location:1001 → 1068
    LRR_8; Leucine rich repeat
    pfam15730
    Location:221 → 297
    DUF4680; Domain of unknown function (DUF4680)
Nucleotide Protein Strain
Heading Accession and Version

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