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NTM neurotrimin [ Homo sapiens (human) ]

Gene ID: 50863, updated on 23-Nov-2021

Summary

Official Symbol
NTMprovided by HGNC
Official Full Name
neurotriminprovided by HGNC
Primary source
HGNC:HGNC:17941
See related
Ensembl:ENSG00000182667 MIM:607938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNT; NTRI; CEPU-1; IGLON2
Summary
This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Expression
Biased expression in brain (RPKM 12.0), lung (RPKM 3.5) and 5 other tissues See more
Orthologs
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Genomic context

See NTM in Genome Data Viewer
Location:
11q25
Exon count:
21
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (131370615..132336822)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (131240510..132206716)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369578 Neighboring gene uncharacterized LOC107984412 Neighboring gene RNA, U6atac small nuclear 12, pseudogene Neighboring gene uncharacterized LOC101929653 Neighboring gene Sharpr-MPRA regulatory region 15285 Neighboring gene GPN-loop GTPase 1 pseudogene Neighboring gene NTM antisense RNA 1 Neighboring gene uncharacterized LOC107984413 Neighboring gene Sharpr-MPRA regulatory region 6145 Neighboring gene VISTA enhancer hs335 Neighboring gene NTM intronic transcript Neighboring gene opioid binding protein/cell adhesion molecule like Neighboring gene uncharacterized LOC105369580 Neighboring gene Sharpr-MPRA regulatory region 13397

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
GeneReviews: Not available
Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
GeneReviews: Not available
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
GeneReviews: Not available
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
GeneReviews: Not available
Genome-wide association study identifies candidate genes for male fertility traits in humans.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available
Variants in several genomic regions associated with asperger disorder.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC60329

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron recognition TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neurotrimin
Names
IgLON family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048209.2NP_001041674.1  neurotrimin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001041674.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and in the coding region compared to variant 3, resulting in a protein that maintains the reading frame but is shorter and has a distinct N-terminus, compared to isoform 3.
    Source sequence(s)
    AA854425, AP004248, AY358331, BE504685
    Consensus CDS
    CCDS41733.1
    UniProtKB/Swiss-Prot
    Q9P121
    Related
    ENSP00000363923.3, ENST00000374791.7
    Conserved Domains (3) summary
    pfam13927
    Location:222299
    Ig_3; Immunoglobulin domain
    cd00096
    Location:223229
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:44132
    Ig; Immunoglobulin domain
  2. NM_001144058.2NP_001137530.1  neurotrimin isoform 3 precursor

    See identical proteins and their annotated locations for NP_001137530.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform 3.
    Source sequence(s)
    AP000844, AP004248, AP005155
    Consensus CDS
    CCDS44777.1
    UniProtKB/Swiss-Prot
    Q9P121
    Related
    ENSP00000396722.2, ENST00000425719.6
    Conserved Domains (3) summary
    smart00409
    Location:233310
    IG; Immunoglobulin
    pfam13927
    Location:136205
    Ig_3; Immunoglobulin domain
    cl11960
    Location:44132
    Ig; Immunoglobulin domain
  3. NM_001144059.3NP_001137531.1  neurotrimin isoform 4 precursor

    See identical proteins and their annotated locations for NP_001137531.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR compared to variant 3. The resulting protein (isoform 4) has a distinct C-terminus, compared to isoform 3.
    Source sequence(s)
    AP000844, AP004248, AP005155
    Consensus CDS
    CCDS44778.1
    UniProtKB/Swiss-Prot
    Q9P121
    Related
    ENSP00000363916.1, ENST00000374784.5
    Conserved Domains (3) summary
    smart00409
    Location:233310
    IG; Immunoglobulin
    pfam13927
    Location:136205
    Ig_3; Immunoglobulin domain
    cl11960
    Location:44132
    Ig; Immunoglobulin domain
  4. NM_001352001.2NP_001338930.1  neurotrimin isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 33, encodes isoform 5.
    Source sequence(s)
    AP000844, AP003166, AP004248, AP005155
    Conserved Domains (3) summary
    pfam13927
    Location:222299
    Ig_3; Immunoglobulin domain
    cd00096
    Location:223229
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:44132
    Ig; Immunoglobulin domain
  5. NM_001352002.2NP_001338931.1  neurotrimin isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP004248, AP005155
    Conserved Domains (3) summary
    smart00409
    Location:233310
    IG; Immunoglobulin
    pfam13927
    Location:136205
    Ig_3; Immunoglobulin domain
    cl11960
    Location:44132
    Ig; Immunoglobulin domain
  6. NM_001352003.2NP_001338932.1  neurotrimin isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP003166, AP004248, AP005155
    Conserved Domains (3) summary
    pfam13927
    Location:222299
    Ig_3; Immunoglobulin domain
    cd00096
    Location:223229
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:44132
    Ig; Immunoglobulin domain
  7. NM_001352004.2NP_001338933.1  neurotrimin isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP004248, AP005155
    Conserved Domains (3) summary
    smart00409
    Location:233310
    IG; Immunoglobulin
    pfam13927
    Location:136205
    Ig_3; Immunoglobulin domain
    cl11960
    Location:44132
    Ig; Immunoglobulin domain
  8. NM_001352005.2NP_001338934.1  neurotrimin isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP003166, AP004248, AP005155
    Related
    ENSP00000507313.1, ENST00000683400.1
    Conserved Domains (3) summary
    pfam13927
    Location:222299
    Ig_3; Immunoglobulin domain
    cd00096
    Location:223229
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:44132
    Ig; Immunoglobulin domain
  9. NM_001352006.2NP_001338935.1  neurotrimin isoform 10

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP003039, AP003166, AP004248, AP005155
    Conserved Domains (3) summary
    smart00409
    Location:224301
    IG; Immunoglobulin
    pfam13927
    Location:127196
    Ig_3; Immunoglobulin domain
    cl11960
    Location:35123
    Ig; Immunoglobulin domain
  10. NM_001352007.2NP_001338936.1  neurotrimin isoform 11

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP003039, AP003166, AP004248, AP005155
    Conserved Domains (3) summary
    smart00409
    Location:224301
    IG; Immunoglobulin
    pfam13927
    Location:127196
    Ig_3; Immunoglobulin domain
    cl11960
    Location:35123
    Ig; Immunoglobulin domain
  11. NM_001352008.2NP_001338937.1  neurotrimin isoform 12

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP004248, AP005155
    Conserved Domains (3) summary
    smart00409
    Location:214291
    IG; Immunoglobulin
    pfam13927
    Location:117186
    Ig_3; Immunoglobulin domain
    cl11960
    Location:25113
    Ig; Immunoglobulin domain
  12. NM_001352009.2NP_001338938.1  neurotrimin isoform 13

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP004248, AP005155
    Conserved Domains (3) summary
    pfam13927
    Location:181258
    Ig_3; Immunoglobulin domain
    cd00096
    Location:182188
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:391
    Ig; Immunoglobulin domain
  13. NM_001386964.1NP_001373893.1  neurotrimin isoform 14

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP004248, AP005155
    Conserved Domains (3) summary
    pfam13927
    Location:208285
    Ig_3; Immunoglobulin domain
    cd00096
    Location:209215
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:3118
    Ig; Immunoglobulin domain
  14. NM_001386965.1NP_001373894.1  neurotrimin isoform 15

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP004248, AP005155
    Conserved Domains (3) summary
    pfam13927
    Location:187264
    Ig_3; Immunoglobulin domain
    cd00096
    Location:188194
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:2197
    Ig; Immunoglobulin domain
  15. NM_001386966.1NP_001373895.1  neurotrimin isoform 16

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variant 36, encodes isoform 16.
    Source sequence(s)
    AP000844, AP004248, AP005155
    Conserved Domains (3) summary
    pfam13927
    Location:181258
    Ig_3; Immunoglobulin domain
    cd00096
    Location:182188
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:391
    Ig; Immunoglobulin domain
  16. NM_001386967.1NP_001373896.1  neurotrimin isoform 17

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP003166, AP004248, AP005155
    Conserved Domains (3) summary
    pfam13927
    Location:217294
    Ig_3; Immunoglobulin domain
    cd00096
    Location:218224
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:51127
    Ig; Immunoglobulin domain
  17. NM_001386968.1NP_001373897.1  neurotrimin isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (33), as well as variant 5, encodes isoform 5.
    Source sequence(s)
    AP000844, AP003166, AP004248, AP005155
    Conserved Domains (3) summary
    pfam13927
    Location:181258
    Ig_3; Immunoglobulin domain
    cd00096
    Location:182188
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:391
    Ig; Immunoglobulin domain
  18. NM_001386969.1NP_001373898.1  neurotrimin isoform 16

    Status: REVIEWED

    Description
    Transcript Variant: This variant (36), as well as variant 23, encodes isoform 16.
    Source sequence(s)
    AP000844, AP003166, AP004248, AP005155
    Conserved Domains (3) summary
    pfam13927
    Location:181258
    Ig_3; Immunoglobulin domain
    cd00096
    Location:182188
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:391
    Ig; Immunoglobulin domain
  19. NM_016522.3NP_057606.1  neurotrimin isoform 1 precursor

    See identical proteins and their annotated locations for NP_057606.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate exon in the 3' coding region, compared to variant 3. This variant encodes isoform 1, which is shorter than isoform 3.
    Source sequence(s)
    AP000844, AP004248, AP005155
    Consensus CDS
    CCDS8491.1
    UniProtKB/Swiss-Prot
    Q9P121
    Related
    ENSP00000363918.1, ENST00000374786.5
    Conserved Domains (3) summary
    pfam13927
    Location:222299
    Ig_3; Immunoglobulin domain
    cd00096
    Location:223229
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:44132
    Ig; Immunoglobulin domain

RNA

  1. NR_147848.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP003166, AP004248, AP005155
  2. NR_147849.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP004248
  3. NR_147850.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP004248, AP005155
  4. NR_147851.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP004248, AP005155
  5. NR_147852.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP004248
  6. NR_147853.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP004248, AP005155
  7. NR_147854.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP004248
  8. NR_170346.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP003039, AP003166, AP004248, AP005155
  9. NR_170347.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP003166, AP004248, AP005155
  10. NR_170348.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP003166, AP004248, AP005155
  11. NR_170349.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP003166, AP004248
  12. NR_170350.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP003166, AP004248, AP005155
  13. NR_170351.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP003039, AP003166, AP004248, AP005155
  14. NR_170352.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP003039, AP003166, AP004248, AP005155
  15. NR_170354.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP003166, AP004248, AP005155
  16. NR_170355.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP003166, AP004248, AP005155
  17. NR_170357.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP003166, AP004248, AP005155
  18. NR_170358.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP003039, AP004248, AP005155
  19. NR_170359.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP004248, AP005155
  20. NR_170360.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP004248, AP005155
  21. NR_170361.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP004248, AP005155
  22. NR_170362.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP004248
    Related
    ENST00000474900.5
  23. NR_170363.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP004248
    Related
    ENST00000539799.5
  24. NR_170364.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP004248
  25. NR_170365.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP004248
  26. NR_170366.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000844, AP003166, AP004248, AP005155

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    131370615..132336822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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