Rnf10 ring finger protein 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf10provided by MGI
Official Full Name: ring finger protein 10provided by MGI
Primary source: MGI:MGI:1859162
See related: Ensembl:ENSMUSG00000041740 AllianceGenome:MGI:1859162
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RIE2; mKIAA0262
Summary: The protein encoding this gene is a member of the really interesting new gene finger protein family. Members of this family contain protein motifs similar to zinc finger domains and are involved in many processes that include transcriptional regulation, DNA repair and signal transduction. Expression of this gene is upregulated during neuronal differentiation of cultured cells, and inhibition of its expression impairs differentiation and cell cycle exit, providing evidence for a function in neuronal differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression: Ubiquitous expression in adrenal adult (RPKM 116.7), testis adult (RPKM 98.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 56.01 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (115379829..115410980, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (115241770..115272921, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results showed that increase in Rnf10 expression upon RA induction is necessary for the positive regulation of cyclin kinase inhibitor p21 expression, which leads to cell cycle arrest and is critical for neuronal differentiation.
Title: RING finger protein 10 regulates retinoic acid-induced neuronal differentiation and the cell cycle exit of P19 embryonic carcinoma cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135502 (e-PCR)
- UniSTS:164932

D5Mit318 (e-PCR), detects polymorphism
- UniSTS:130460

AA675014 (e-PCR)
- UniSTS:159429

Homology

Homologs of the Rnf10 gene: The Rnf10 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 493 organisms have orthologs with human gene Rnf10
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of Schwann cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myelination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in postsynapse to nucleus signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RING finger protein 10

Names: sid 2705

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302448.1 → NP_001289377.1 RING finger protein 10 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AA792805, AC145070, AK004579, AK146728

Consensus CDS

CCDS80381.1

UniProtKB/Swiss-Prot

Q3UIW5

UniProtKB/TrEMBL

D3Z1N2

Related

ENSMUSP00000107726.2, ENSMUST00000112097.8

Conserved Domains (1) summary

pfam13923
Location:225 → 266

zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
NM_001302449.1 → NP_001289378.1 RING finger protein 10 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses alternate in-frame splice sites in the coding region compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AA792805, AC145070, AK034953, AK146728

Consensus CDS

CCDS80380.1

UniProtKB/Swiss-Prot

Q3UIW5

UniProtKB/TrEMBL

H7BX06

Related

ENSMUSP00000041778.9, ENSMUST00000040555.15

Conserved Domains (1) summary

pfam13923
Location:225 → 266

zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
NM_016698.2 → NP_057907.2 RING finger protein 10 isoform 2

See identical proteins and their annotated locations for NP_057907.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AK129106, AK146728, AV451382

Consensus CDS

CCDS19584.1

UniProtKB/Swiss-Prot

Q3UIW5, Q9R0P0

Related

ENSMUSP00000107725.3, ENSMUST00000112096.9

Conserved Domains (1) summary

pfam13923
Location:225 → 266

zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

115379829..115410980 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320970.2 → XP_017176459.1 RING finger protein 10 isoform X1

Conserved Domains (1) summary

cd16536
Location:225 → 267

RING-HC_RNF10; RING finger, HC subclass, found in RING finger protein 10 (RNF10) and similar proteins