U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TAS2R14 taste 2 receptor member 14 [ Homo sapiens (human) ]

Gene ID: 50840, updated on 22-Sep-2022

Summary

Official Symbol
TAS2R14provided by HGNC
Official Full Name
taste 2 receptor member 14provided by HGNC
Primary source
HGNC:HGNC:14920
See related
Ensembl:ENSG00000212127 MIM:604790; AllianceGenome:HGNC:14920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRB1; T2R14
Summary
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TAS2R14 in Genome Data Viewer
Location:
12p13.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10937410..10939263, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10810447..10812300, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (11090009..11091862, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene PRH1-PRR4 readthrough Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene taste 2 receptor member 13 Neighboring gene PRH1-TAS2R14 readthrough Neighboring gene proline rich protein HaeIII subfamily 2 Neighboring gene taste 2 receptor member 15 pseudogene Neighboring gene taste 2 receptor member 50

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough PRH1-TAS2R14

Readthrough gene: PRH1-TAS2R14, Included gene: PRH1

Homology

Clone Names

  • MGC125491, MGC125492

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables bitter taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables bitter taste receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables taste receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables taste receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
taste receptor type 2 member 14
Names
taste receptor, family B, member 1
taste receptor, type 2, member 14

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023922.2NP_076411.1  taste receptor type 2 member 14

    See identical proteins and their annotated locations for NP_076411.1

    Status: REVIEWED

    Source sequence(s)
    AC006518
    Consensus CDS
    CCDS8637.1
    UniProtKB/Swiss-Prot
    Q645X3, Q9NYV8
    Related
    ENSP00000441949.1, ENST00000537503.2
    Conserved Domains (1) summary
    cd15019
    Location:8295
    7tm_TAS2R14-like; mammalian taste receptor 2, subtype 14, member of the seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    10937410..10939263 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571050.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    136116..137969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    136116..137969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    10810447..10812300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)