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DHX58 DExH-box helicase 58 [ Bos taurus (domestic cattle) ]

Gene ID: 508378, updated on 1-Jan-2025

Summary

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Official Symbol
DHX58provided by VGNC
Official Full Name
DExH-box helicase 58provided by VGNC
Primary source
VGNC:VGNC:28058
See related
Ensembl:ENSBTAG00000046580
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
LGP2
Orthologs
human mouse all
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Genomic context

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See DHX58 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (42237043..42247590, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene NFKB inhibitor interacting Ras like 2 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 19 C17orf113 homolog Neighboring gene lysine acetyltransferase 2A Neighboring gene heat shock protein family B (small) member 9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2. Komuro A, et al. J Virol, 2006 Dec. PMID 17020950, Free PMC Article
  2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional analysis of the human LGP2 ortholog.
    Title: RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables single-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antiviral innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytoplasmic pattern recognition receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of RIG-I signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ATP-dependent RNA helicase DHX58
Names
DEXH (Asp-Glu-X-His) box polypeptide 58
RNA helicase LGP2
NP_001015545.1
XP_024835624.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015545.1 → NP_001015545.1  ATP-dependent RNA helicase DHX58

    See identical proteins and their annotated locations for NP_001015545.1

    Status: PROVISIONAL

    Source sequence(s)
    BT020952
    UniProtKB/TrEMBL
    Q5E9G8
    Related
    ENSBTAP00000055976.2, ENSBTAT00000065738.3
    Conserved Domains (4) summary
    cd12090
    Location:227 → 343
    MDA5_ID; Insert domain of MDA5
    pfam00271
    Location:350 → 475
    Helicase_C; Helicase conserved C-terminal domain
    pfam04851
    Location:1 → 170
    ResIII; Type III restriction enzyme, res subunit
    cl13152
    Location:555 → 667
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    42237043..42247590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024979856.2 → XP_024835624.1  ATP-dependent RNA helicase DHX58 isoform X1

    UniProtKB/TrEMBL
    G3N268
    Conserved Domains (2) summary
    cl13152
    Location:555 → 667
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
    cl17041
    Location:2 → 492
    helicase_insert_domain
Nucleotide Protein Strain
Heading Accession and Version

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