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TAS2R1 taste 2 receptor member 1 [ Homo sapiens (human) ]

Gene ID: 50834, updated on 23-Nov-2021

Summary

Official Symbol
TAS2R1provided by HGNC
Official Full Name
taste 2 receptor member 1provided by HGNC
Primary source
HGNC:HGNC:14909
See related
Ensembl:ENSG00000169777 MIM:604796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T2R1; TRB7
Summary
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See TAS2R1 in Genome Data Viewer
Location:
5p15.31
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (9627347..9903876, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (9627459..9903988, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 123 Neighboring gene uncharacterized LOC101929359 Neighboring gene small nucleolar RNA host gene 18 Neighboring gene long intergenic non-protein coding RNA 2112 Neighboring gene uncharacterized LOC105374649 Neighboring gene RNA, 5S ribosomal pseudogene 177 Neighboring gene long intergenic non-protein coding RNA 2221 Neighboring gene uncharacterized LOC107986405 Neighboring gene ATP synthase c subunit lysine N-methyltransferase

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide linkage and association scan reveals novel loci for autism.
GeneReviews: Not available
Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia.
GeneReviews: Not available

General gene information

Markers

Homology

Clone Names

  • MGC126778, MGC126780

General protein information

Preferred Names
taste receptor type 2 member 1
Names
taste receptor, family B, member 7
taste receptor, type 2, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386348.1NP_001373277.1  taste receptor type 2 member 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC026787, AC034214, AC091958
    Conserved Domains (1) summary
    cd15016
    Location:1249
    7tm_TAS2R1; mammalian taste receptor 2, subtype 1, member of the seven-transmembrane G protein-coupled receptor superfamily
  2. NM_019599.3NP_062545.1  taste receptor type 2 member 1 isoform 1

    See identical proteins and their annotated locations for NP_062545.1

    Status: REVIEWED

    Source sequence(s)
    AC034214
    Consensus CDS
    CCDS3876.1
    UniProtKB/Swiss-Prot
    Q9NYW7
    UniProtKB/TrEMBL
    Q502V6
    Related
    ENSP00000371932.2, ENST00000382492.4
    Conserved Domains (1) summary
    pfam05296
    Location:1296
    TAS2R; Taste receptor protein (TAS2R)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    9627347..9903876 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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