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HP1BP3 heterochromatin protein 1 binding protein 3 [ Homo sapiens (human) ]

Gene ID: 50809, updated on 4-Dec-2022

Summary

Official Symbol
HP1BP3provided by HGNC
Official Full Name
heterochromatin protein 1 binding protein 3provided by HGNC
Primary source
HGNC:HGNC:24973
See related
Ensembl:ENSG00000127483 MIM:616072; AllianceGenome:HGNC:24973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HP1BP74; HP1-BP74
Summary
Enables DNA binding activity and nucleosome binding activity. Involved in several processes, including cellular response to hypoxia; heterochromatin organization; and regulation of nucleus size. Located in chromosome and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 36.6), endometrium (RPKM 35.9) and 25 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See HP1BP3 in Genome Data Viewer
Location:
1p36.12
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (20740266..20787307, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (20566829..20613865, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (21066759..21113800, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene kinesin family member 17 Neighboring gene SH2 domain containing 5 Neighboring gene eukaryotic translation initiation factor 4 gamma 3 Neighboring gene RNA, U7 small nuclear 200 pseudogene Neighboring gene uncharacterized LOC105376830 Neighboring gene uncharacterized LOC105376829

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC43701

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heterochromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heterochromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of nucleus size IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heterochromatin protein 1-binding protein 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372052.1NP_001358981.1  heterochromatin protein 1-binding protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074
    Consensus CDS
    CCDS30621.1
    UniProtKB/Swiss-Prot
    Q9UHY0
    Related
    ENSP00000403039.2, ENST00000438032.6
    Conserved Domains (4) summary
    smart00526
    Location:253319
    H15; Domain in histone families 1 and 5
    PRK14900
    Location:455531
    valS; valyl-tRNA synthetase; Provisional
    cd00073
    Location:155245
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:346411
    Linker_histone; linker histone H1 and H5 family
  2. NM_001376787.1NP_001363716.1  heterochromatin protein 1-binding protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074
    Consensus CDS
    CCDS30621.1
    UniProtKB/Swiss-Prot
    Q9UHY0
    Conserved Domains (4) summary
    smart00526
    Location:253319
    H15; Domain in histone families 1 and 5
    PRK14900
    Location:455531
    valS; valyl-tRNA synthetase; Provisional
    cd00073
    Location:155245
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:346411
    Linker_histone; linker histone H1 and H5 family
  3. NM_001376788.1NP_001363717.1  heterochromatin protein 1-binding protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074
    Consensus CDS
    CCDS30621.1
    UniProtKB/Swiss-Prot
    Q9UHY0
    Conserved Domains (4) summary
    smart00526
    Location:253319
    H15; Domain in histone families 1 and 5
    PRK14900
    Location:455531
    valS; valyl-tRNA synthetase; Provisional
    cd00073
    Location:155245
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:346411
    Linker_histone; linker histone H1 and H5 family
  4. NM_001376789.1NP_001363718.1  heterochromatin protein 1-binding protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074
    Consensus CDS
    CCDS30621.1
    UniProtKB/Swiss-Prot
    Q9UHY0
    Conserved Domains (4) summary
    smart00526
    Location:253319
    H15; Domain in histone families 1 and 5
    PRK14900
    Location:455531
    valS; valyl-tRNA synthetase; Provisional
    cd00073
    Location:155245
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:346411
    Linker_histone; linker histone H1 and H5 family
  5. NM_001376790.1NP_001363719.1  heterochromatin protein 1-binding protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074
    Consensus CDS
    CCDS30621.1
    UniProtKB/Swiss-Prot
    Q9UHY0
    Conserved Domains (4) summary
    smart00526
    Location:253319
    H15; Domain in histone families 1 and 5
    PRK14900
    Location:455531
    valS; valyl-tRNA synthetase; Provisional
    cd00073
    Location:155245
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:346411
    Linker_histone; linker histone H1 and H5 family
  6. NM_001376791.1NP_001363720.1  heterochromatin protein 1-binding protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074
    Conserved Domains (4) summary
    smart00526
    Location:215281
    H15; Domain in histone families 1 and 5
    PRK14900
    Location:417493
    valS; valyl-tRNA synthetase; Provisional
    cd00073
    Location:117207
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:308373
    Linker_histone; linker histone H1 and H5 family
  7. NM_001376792.1NP_001363721.1  heterochromatin protein 1-binding protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074
    Conserved Domains (4) summary
    smart00526
    Location:215281
    H15; Domain in histone families 1 and 5
    PRK14900
    Location:417493
    valS; valyl-tRNA synthetase; Provisional
    cd00073
    Location:117207
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:308373
    Linker_histone; linker histone H1 and H5 family
  8. NM_001376793.1NP_001363722.1  heterochromatin protein 1-binding protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074
    Conserved Domains (4) summary
    smart00526
    Location:215281
    H15; Domain in histone families 1 and 5
    PRK14900
    Location:417493
    valS; valyl-tRNA synthetase; Provisional
    cd00073
    Location:117207
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:308373
    Linker_histone; linker histone H1 and H5 family
  9. NM_001376794.1NP_001363723.1  heterochromatin protein 1-binding protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074
    Conserved Domains (4) summary
    smart00526
    Location:215281
    H15; Domain in histone families 1 and 5
    PRK14900
    Location:417493
    valS; valyl-tRNA synthetase; Provisional
    cd00073
    Location:117207
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:308373
    Linker_histone; linker histone H1 and H5 family
  10. NM_001376795.1NP_001363724.1  heterochromatin protein 1-binding protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074
    Conserved Domains (2) summary
    smart00526
    Location:253319
    H15; Domain in histone families 1 and 5
    cd00073
    Location:155245
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
  11. NM_001376796.1NP_001363725.1  heterochromatin protein 1-binding protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074
    Conserved Domains (2) summary
    smart00526
    Location:253319
    H15; Domain in histone families 1 and 5
    cd00073
    Location:155245
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
  12. NM_001376797.1NP_001363726.1  heterochromatin protein 1-binding protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074
    Related
    ENSP00000402754.1, ENST00000424732.5
    Conserved Domains (2) summary
    smart00526
    Location:215281
    H15; Domain in histone families 1 and 5
    cd00073
    Location:117207
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
  13. NM_001399820.1NP_001386749.1  heterochromatin protein 1-binding protein 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074
  14. NM_001399821.1NP_001386750.1  heterochromatin protein 1-binding protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074
  15. NM_001399823.1NP_001386752.1  heterochromatin protein 1-binding protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074
  16. NM_016287.5NP_057371.2  heterochromatin protein 1-binding protein 3 isoform 1

    See identical proteins and their annotated locations for NP_057371.2

    Status: VALIDATED

    Source sequence(s)
    AK023129, AL663074
    Consensus CDS
    CCDS30621.1
    UniProtKB/Swiss-Prot
    Q5SSJ5, Q9UHY0
    Related
    ENSP00000312625.5, ENST00000312239.10
    Conserved Domains (4) summary
    smart00526
    Location:253319
    H15; Domain in histone families 1 and 5
    PRK14900
    Location:455531
    valS; valyl-tRNA synthetase; Provisional
    cd00073
    Location:155245
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:346411
    Linker_histone; linker histone H1 and H5 family

RNA

  1. NR_164850.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074
  2. NR_164851.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606477, AL663074

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    20740266..20787307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    20566829..20613865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)