Format

Send to:

Choose Destination

MYEF2 myelin expression factor 2 [ Homo sapiens (human) ]

Gene ID: 50804, updated on 12-Oct-2019

Summary

Official Symbol
MYEF2provided by HGNC
Official Full Name
myelin expression factor 2provided by HGNC
Primary source
HGNC:HGNC:17940
See related
Ensembl:ENSG00000104177
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEF-2; MST156; myEF-2; MSTP156; HsT18564
Expression
Broad expression in brain (RPKM 7.4), testis (RPKM 5.4) and 22 other tissues See more
Orthologs

Genomic context

See MYEF2 in Genome Data Viewer
Location:
15q21.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (48134632..48178517, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (48431629..48470714, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370805 Neighboring gene uncharacterized LOC102724553 Neighboring gene uncharacterized LOC107984792 Neighboring gene uncharacterized LOC107984136 Neighboring gene solute carrier family 24 member 5 Neighboring gene uncharacterized LOC105370807 Neighboring gene uncharacterized LOC112267905 Neighboring gene cortexin 2 Neighboring gene solute carrier family 12 member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of myelin expression factor 2 (MYEF2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11213, KIAA1341, MGC87325

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
myotube differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
neuron differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of mRNA stability involved in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
post-mRNA release spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
myelin expression factor 2
Names
myelin gene expression factor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301210.2NP_001288139.2  myelin expression factor 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC066612, AC090526, KF456039
    Consensus CDS
    CCDS73722.1
    Related
    ENSP00000267836.6, ENST00000267836.10
  2. NM_016132.5NP_057216.3  myelin expression factor 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC066612, AC090526, KF456039
    Consensus CDS
    CCDS32230.1
    Related
    ENSP00000316950.7, ENST00000324324.12
    Conserved Domains (4) summary
    cd12386
    Location:235308
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:101176
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:524600
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
    cl25887
    Location:124596
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_125408.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' region, and also lacks several 3' exons but includes an alternate 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC066612, AC090526
    Related
    ENST00000561351.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    48134632..48178517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022287.1XP_016877776.1  myelin expression factor 2 isoform X6

  2. XM_017022285.1XP_016877774.1  myelin expression factor 2 isoform X4

  3. XM_017022286.1XP_016877775.1  myelin expression factor 2 isoform X5

  4. XM_005254425.4XP_005254482.2  myelin expression factor 2 isoform X3

    Conserved Domains (2) summary
    cd12386
    Location:235308
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:101176
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
  5. XM_017022292.1XP_016877781.1  myelin expression factor 2 isoform X14

  6. XM_017022291.1XP_016877780.1  myelin expression factor 2 isoform X13

  7. XM_006720553.3XP_006720616.1  myelin expression factor 2 isoform X7

    See identical proteins and their annotated locations for XP_006720616.1

    UniProtKB/TrEMBL
    A0A024R5Q6
    Conserved Domains (4) summary
    COG0724
    Location:338440
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12386
    Location:75148
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12662
    Location:364440
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
    cl17169
    Location:116
    RRM_SF; RNA recognition motif (RRM) superfamily
  8. XM_011521657.2XP_011519959.1  myelin expression factor 2 isoform X8

    Conserved Domains (3) summary
    COG0724
    Location:334436
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12386
    Location:71144
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12662
    Location:360436
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
  9. XM_005254422.4XP_005254479.2  myelin expression factor 2 isoform X1

    Conserved Domains (4) summary
    TIGR01628
    Location:124579
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12386
    Location:235308
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:101176
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:507583
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
  10. XM_017022290.1XP_016877779.1  myelin expression factor 2 isoform X11

  11. XM_017022288.1XP_016877777.1  myelin expression factor 2 isoform X9

  12. XM_017022289.1XP_016877778.1  myelin expression factor 2 isoform X10

    Conserved Domains (4) summary
    COG0724
    Location:314416
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12386
    Location:75148
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12662
    Location:340416
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
    cl17169
    Location:116
    RRM_SF; RNA recognition motif (RRM) superfamily
  13. XM_005254424.4XP_005254481.2  myelin expression factor 2 isoform X2

    Conserved Domains (4) summary
    TIGR01628
    Location:124555
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12386
    Location:235308
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:101176
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:483559
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
  14. XM_005254427.4XP_005254484.1  myelin expression factor 2 isoform X12

    Conserved Domains (2) summary
    cd12386
    Location:235308
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:101176
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
Support Center