U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KCNK4 potassium two pore domain channel subfamily K member 4 [ Homo sapiens (human) ]

Gene ID: 50801, updated on 17-Feb-2024

Summary

Official Symbol
KCNK4provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 4provided by HGNC
Primary source
HGNC:HGNC:6279
See related
Ensembl:ENSG00000182450 MIM:605720; AllianceGenome:HGNC:6279
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FHEIG; TRAAK; K2p4.1; TRAAK1
Summary
This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]
Expression
Biased expression in brain (RPKM 1.0), placenta (RPKM 0.2) and 2 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See KCNK4 in Genome Data Viewer
Location:
11q13.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64291302..64300031)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64281266..64289999)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64058774..64067503)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64019089-64019734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64019735-64020381 Neighboring gene phospholipase C beta 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4893 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4894 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:64038093-64038658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4896 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64042574-64043234 Neighboring gene G protein-coupled receptor 137 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64043895-64044554 Neighboring gene BCL2 associated agonist of cell death Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64046081-64046582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3475 Neighboring gene KCNK4-CATSPERZ readthrough (NMD candidate) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64066730-64067724 Neighboring gene catsper channel auxiliary subunit zeta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4897 Neighboring gene estrogen related receptor alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64083535-64084050 Neighboring gene tRNA methyltransferase activator subunit 11-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough KCNK4-CATSPERZ

Readthrough gene: KCNK4-CATSPERZ, Included gene: CATSPERZ

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mechanosensitived potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables temperature-gated cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cellular response to alkaline pH ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to fatty acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to mechanical stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to temperature stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in detection of mechanical stimulus involved in sensory perception of touch ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in memory IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
involved_in sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sensory perception of temperature stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
potassium channel subfamily K member 4
Names
K2P4.1 potassium channel
TWIK-related arachidonic acid-stimulated potassium channel protein
potassium channel, subfamily K, member 4
potassium channel, two pore domain subfamily K, member 4
two pore K(+) channel KT4.1
two pore K+ channel KT4.1
two pore potassium channel KT4.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317090.2NP_001304019.1  potassium channel subfamily K member 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 2. Both variants 2 and 4 encode the same protein.
    Source sequence(s)
    AP001453, BC110327
    Consensus CDS
    CCDS8067.1
    UniProtKB/Swiss-Prot
    B5TJL1, Q96T94, Q9NYG8
    UniProtKB/TrEMBL
    Q2YDA1
    Related
    ENSP00000378033.2, ENST00000394525.6
    Conserved Domains (1) summary
    pfam07885
    Location:88142
    Ion_trans_2; Ion channel
  2. NM_033310.3NP_201567.1  potassium channel subfamily K member 4

    See identical proteins and their annotated locations for NP_201567.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the functional protein.
    Source sequence(s)
    AF259500, AP001453, BC067791, BC110327, DB273064
    Consensus CDS
    CCDS8067.1
    UniProtKB/Swiss-Prot
    B5TJL1, Q96T94, Q9NYG8
    UniProtKB/TrEMBL
    Q2YDA1
    Related
    ENSP00000402797.2, ENST00000422670.7
    Conserved Domains (1) summary
    pfam07885
    Location:88142
    Ion_trans_2; Ion channel

RNA

  1. NR_133660.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' most exon, lacks an internal exon and uses an alternate splice site in an internal exon compared to variant 2. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AP001453, BC067791
    Related
    ENST00000538767.1
  2. NR_133661.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' most exon and uses an alternate splice site in an internal exon compared to variant 2. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AP001453, BC033577
    Related
    ENST00000541349.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    64291302..64300031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    64281266..64289999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016611.2: Suppressed sequence

    Description
    NM_016611.2: This RefSeq was permanently suppressed because it is a rare readthrough transcript.