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KCNK4 potassium two pore domain channel subfamily K member 4 [ Homo sapiens (human) ]

Gene ID: 50801, updated on 27-Jun-2020

Summary

Official Symbol
KCNK4provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 4provided by HGNC
Primary source
HGNC:HGNC:6279
See related
Ensembl:ENSG00000182450 MIM:605720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FHEIG; TRAAK; K2p4.1; TRAAK1
Summary
This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]
Expression
Biased expression in brain (RPKM 1.0), placenta (RPKM 0.2) and 2 other tissues See more
Orthologs

Genomic context

See KCNK4 in Genome Data Viewer
Location:
11q13.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (64291302..64300031)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64058774..64067503)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene phospholipase C beta 3 Neighboring gene G protein-coupled receptor 137 Neighboring gene BCL2 associated agonist of cell death Neighboring gene KCNK4-TEX40 readthrough Neighboring gene catsper channel auxiliary subunit zeta Neighboring gene estrogen related receptor alpha Neighboring gene tRNA methyltransferase subunit 11-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough KCNK4-TEX40

Readthrough gene: KCNK4-TEX40, Included gene: CATSPERZ

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mechanosensitived potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
temperature-gated cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to alkaline pH ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to fatty acid IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to mechanical stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to temperature stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
detection of mechanical stimulus involved in sensory perception of touch ISS
Inferred from Sequence or Structural Similarity
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
sensory perception of temperature stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
potassium channel subfamily K member 4
Names
K2P4.1 potassium channel
TWIK-related arachidonic acid-stimulated potassium channel protein
potassium channel, subfamily K, member 4
potassium channel, two pore domain subfamily K, member 4
two pore K(+) channel KT4.1
two pore K+ channel KT4.1
two pore potassium channel KT4.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317090.2NP_001304019.1  potassium channel subfamily K member 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 2. Both variants 2 and 4 encode the same protein.
    Source sequence(s)
    AP001453, BC110327
    Consensus CDS
    CCDS8067.1
    UniProtKB/Swiss-Prot
    Q9NYG8
    UniProtKB/TrEMBL
    A0A024R5C7, Q2YDA1
    Related
    ENSP00000378033.2, ENST00000394525.6
    Conserved Domains (1) summary
    pfam07885
    Location:88142
    Ion_trans_2; Ion channel
  2. NM_033310.3NP_201567.1  potassium channel subfamily K member 4 precursor

    See identical proteins and their annotated locations for NP_201567.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the functional protein.
    Source sequence(s)
    AF259500, AP001453, BC067791, BC110327, DB273064
    Consensus CDS
    CCDS8067.1
    UniProtKB/Swiss-Prot
    Q9NYG8
    UniProtKB/TrEMBL
    A0A024R5C7, Q2YDA1
    Related
    ENSP00000402797.2, ENST00000422670.7
    Conserved Domains (1) summary
    pfam07885
    Location:88142
    Ion_trans_2; Ion channel

RNA

  1. NR_133660.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' most exon, lacks an internal exon and uses an alternate splice site in an internal exon compared to variant 2. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AP001453, BC067791
    Related
    ENST00000538767.1
  2. NR_133661.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' most exon and uses an alternate splice site in an internal exon compared to variant 2. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AP001453, BC033577
    Related
    ENST00000541349.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    64291302..64300031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016611.2: Suppressed sequence

    Description
    NM_016611.2: This RefSeq was permanently suppressed because it is a rare readthrough transcript.
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