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Slc25a13 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 [ Mus musculus (house mouse) ]

Gene ID: 50799, updated on 8-Dec-2022

Summary

Official Symbol
Slc25a13provided by MGI
Official Full Name
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13provided by MGI
Primary source
MGI:MGI:1354721
See related
Ensembl:ENSMUSG00000015112 AllianceGenome:MGI:1354721
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ctrn
Summary
Enables L-glutamate transmembrane transporter activity. Acts upstream of or within aspartate transmembrane transport and malate-aspartate shuttle. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and nose. Used to study citrullinemia. Human ortholog(s) of this gene implicated in adult-onset type II citrullinemia and neonatal-onset type II citrullinemia. Orthologous to human SLC25A13 (solute carrier family 25 member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 28.1), liver adult (RPKM 15.6) and 12 other tissues See more
Orthologs
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Genomic context

See Slc25a13 in Genome Data Viewer
Location:
6; 6 A1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (6041218..6217304, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (6041218..6217304, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene dynein cytoplasmic 1 intermediate chain 1 Neighboring gene predicted gene, 34527 Neighboring gene RIKEN cDNA 1700019G24 gene Neighboring gene predicted gene 20619 Neighboring gene predicted gene, 34749 Neighboring gene predicted gene 8649

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in L-glutamate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in L-glutamate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within aspartate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aspartate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular respiration ISO
Inferred from Sequence Orthology
more info
 
involved_in gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in malate-aspartate shuttle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within malate-aspartate shuttle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in malate-aspartate shuttle ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane HDA PubMed 
is_active_in mitochondrial inner membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial; calcium-binding mitochondrial carrier protein Aralar2
Names
citrin
mitochondrial aspartate glutamate carrier 2
solute carrier family 25, member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177572.2NP_001171043.1  electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001171043.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC023175, AC091396
    UniProtKB/Swiss-Prot
    Q9QXX4
    UniProtKB/TrEMBL
    Q8C140
    Conserved Domains (4) summary
    PTZ00168
    Location:327585
    PTZ00168; mitochondrial carrier protein; Provisional
    pfam00153
    Location:516608
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1781
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:1981
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. NM_001410674.1NP_001397603.1  electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC023175, AC091396
  3. NM_001410675.1NP_001397604.1  electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC023175, AC091396
  4. NM_001410676.1NP_001397605.1  electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC023175, AC091396
  5. NM_001410677.1NP_001397606.1  electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC091396
  6. NM_015829.4NP_056644.1  electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_056644.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC023175, AC091396
    Consensus CDS
    CCDS39421.1
    UniProtKB/Swiss-Prot
    Q9DCF5, Q9QXX4
    Related
    ENSMUSP00000139571.2, ENSMUST00000188414.4
    Conserved Domains (4) summary
    PTZ00168
    Location:328586
    PTZ00168; mitochondrial carrier protein; Provisional
    pfam00153
    Location:517609
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1781
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:1981
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    6041218..6217304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255494.1XP_030111354.1  calcium-binding mitochondrial carrier protein Aralar2 isoform X2

    Conserved Domains (4) summary
    cd15897
    Location:5792
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:54187
    EFh_PEF; The penta-EF hand (PEF) family
    pfam00153
    Location:329421
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1881
    EF-hand_7; EF-hand domain pair
  2. XM_006505136.4XP_006505199.1  calcium-binding mitochondrial carrier protein Aralar2 isoform X1

    Conserved Domains (4) summary
    cd15897
    Location:5792
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:54187
    EFh_PEF; The penta-EF hand (PEF) family
    pfam00153
    Location:330422
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1881
    EF-hand_7; EF-hand domain pair
  3. XM_036166276.1XP_036022169.1  calcium-binding mitochondrial carrier protein Aralar2 isoform X4

    Conserved Domains (4) summary
    cd15897
    Location:5792
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:54187
    EFh_PEF; The penta-EF hand (PEF) family
    pfam00153
    Location:329422
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1881
    EF-hand_7; EF-hand domain pair
  4. XM_006505137.4XP_006505200.1  calcium-binding mitochondrial carrier protein Aralar2 isoform X3

    Conserved Domains (4) summary
    cd15897
    Location:5792
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:54187
    EFh_PEF; The penta-EF hand (PEF) family
    pfam00153
    Location:330422
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1881
    EF-hand_7; EF-hand domain pair