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Fbxl3 F-box and leucine-rich repeat protein 3 [ Mus musculus (house mouse) ]

Gene ID: 50789, updated on 24-Oct-2019

Summary

Official Symbol
Fbxl3provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 3provided by MGI
Primary source
MGI:MGI:1354702
See related
Ensembl:ENSMUSG00000022124
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBK; Ovtm; Fbl3a; Fbxl3a; Play68; AU041772; AW212966
Expression
Ubiquitous expression in cerebellum adult (RPKM 14.1), bladder adult (RPKM 13.9) and 28 other tissues See more
Orthologs

Genomic context

See Fbxl3 in Genome Data Viewer
Location:
14; 14 E2.3
Exon count:
6
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (103080239..103099566, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (103479456..103498726, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41236 Neighboring gene ceroid-lipofuscinosis, neuronal 5 Neighboring gene MYC binding protein 2, E3 ubiquitin protein ligase Neighboring gene predicted gene, 34758 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
entrainment of circadian clock by photoperiod IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nuclear body ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
F-box/LRR-repeat protein 3
Names
F-box and leucine-rich repeat protein 3a
F-box/LRR-repeat protein 3A
protein after-hours
protein overtime

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347600.1NP_001334529.1  F-box/LRR-repeat protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC102815, AK142007, BY146960, BY276318
    Consensus CDS
    CCDS84159.1
    UniProtKB/TrEMBL
    Q5PRF6
  2. NM_001347601.1NP_001334530.1  F-box/LRR-repeat protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC102815, AK142007, BY276318
    Consensus CDS
    CCDS84159.1
    UniProtKB/TrEMBL
    Q5PRF6
    Related
    ENSMUSP00000115843.1, ENSMUST00000132004.7
  3. NM_001360341.1NP_001347270.1  F-box/LRR-repeat protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC102815, AK142007, BC067203
    Consensus CDS
    CCDS27315.1
    Related
    ENSMUSP00000116044.1, ENSMUST00000145693.7
    Conserved Domains (2) summary
    sd00034
    Location:174199
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:3677
    F-box-like; F-box-like
  4. NM_001360342.1NP_001347271.1  F-box/LRR-repeat protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC102815, AK142007, BC067203, BY146960
    Consensus CDS
    CCDS27315.1
    Conserved Domains (2) summary
    sd00034
    Location:174199
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:3677
    F-box-like; F-box-like
  5. NM_015822.3NP_056637.1  F-box/LRR-repeat protein 3 isoform 1

    See identical proteins and their annotated locations for NP_056637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK142007, BY787665
    Consensus CDS
    CCDS27315.1
    UniProtKB/Swiss-Prot
    Q8C4V4
    UniProtKB/TrEMBL
    Q5PRF6
    Related
    ENSMUSP00000022720.8, ENSMUST00000022720.14
    Conserved Domains (2) summary
    sd00034
    Location:174199
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:3677
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p6 C57BL/6J

    Range
    103080239..103099566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519240.4XP_006519303.1  F-box/LRR-repeat protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006519303.1

    UniProtKB/Swiss-Prot
    Q8C4V4
    Conserved Domains (3) summary
    cd09293
    Location:279360
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:126151
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:3669
    F-box-like; F-box-like
  2. XM_006519243.4XP_006519306.1  F-box/LRR-repeat protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006519306.1

    UniProtKB/TrEMBL
    Q8BNS3
    Conserved Domains (2) summary
    cd09293
    Location:175256
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:2247
    LRR_AMN1; leucine-rich repeat [structural motif]
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