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Fbxl8 F-box and leucine-rich repeat protein 8 [ Mus musculus (house mouse) ]

Gene ID: 50788, updated on 10-Oct-2019

Summary

Official Symbol
Fbxl8provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 8provided by MGI
Primary source
MGI:MGI:1354697
See related
Ensembl:ENSMUSG00000033313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBL8
Expression
Broad expression in colon adult (RPKM 13.7), duodenum adult (RPKM 10.0) and 19 other tissues See more
Orthologs

Genomic context

See Fbxl8 in Genome Data Viewer
Location:
8; 8 D3
Exon count:
4
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105264648..105269326)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (107788548..107793226)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D230025D16 gene Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Neighboring gene TNFRSF1A-associated via death domain Neighboring gene heat shock transcription factor 4 Neighboring gene RIKEN cDNA 4931428F04 gene Neighboring gene nucleolar protein 3 (apoptosis repressor with CARD domain)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
F-box/LRR-repeat protein 8
Names
F-box protein FBL8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015821.2NP_056636.2  F-box/LRR-repeat protein 8

    See identical proteins and their annotated locations for NP_056636.2

    Status: VALIDATED

    Source sequence(s)
    AC124584, CX222518
    Consensus CDS
    CCDS22595.1
    UniProtKB/Swiss-Prot
    Q8CIG9
    UniProtKB/TrEMBL
    Q3TD55
    Related
    ENSMUSP00000038638.5, ENSMUST00000036221.11
    Conserved Domains (2) summary
    sd00034
    Location:103136
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:533
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p6 C57BL/6J

    Range
    105264648..105269326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243666.1XP_030099526.1  F-box/LRR-repeat protein 8 isoform X2

  2. XM_011248436.2XP_011246738.2  F-box/LRR-repeat protein 8 isoform X1

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