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Hs6st3 heparan sulfate 6-O-sulfotransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 50787, updated on 8-Nov-2022

Summary

Official Symbol
Hs6st3provided by MGI
Official Full Name
heparan sulfate 6-O-sulfotransferase 3provided by MGI
Primary source
MGI:MGI:1354960
See related
Ensembl:ENSMUSG00000053465 AllianceGenome:MGI:1354960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6OST3; HS6ST-3
Summary
Enables heparan sulfate 6-O-sulfotransferase activity. Acts upstream of or within heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system; dorsal aorta; genitourinary system; limb primordium; and sensory organ. Orthologous to human HS6ST3 (heparan sulfate 6-O-sulfotransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 1.3), frontal lobe adult (RPKM 0.8) and 7 other tissues See more
Orthologs
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Genomic context

See Hs6st3 in Genome Data Viewer
Location:
14; 14 E4
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (119374902..120226864)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (119137516..119869815)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C3 Neighboring gene coiled-coil domain-containing protein 58 pseudogene Neighboring gene UDP-glucose glycoprotein glucosyltransferase 2 Neighboring gene predicted gene, 16835 Neighboring gene tera pseudogene Neighboring gene RIKEN cDNA 1700006F04 gene Neighboring gene CD24a antigen pseudogene Neighboring gene RIKEN cDNA 4930404K13 gene Neighboring gene predicted gene, 41249 Neighboring gene GABA(A) receptor-associated protein-like 2 pseudogene Neighboring gene oxoglutarate (alpha-ketoglutarate) receptor 1 Neighboring gene 60S ribosomal protein L39 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC144859, MGC144860

General protein information

Preferred Names
heparan-sulfate 6-O-sulfotransferase 3
NP_056635.2
XP_006519301.1
XP_011243415.1
XP_036014643.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015820.3NP_056635.2  heparan-sulfate 6-O-sulfotransferase 3 precursor

    See identical proteins and their annotated locations for NP_056635.2

    Status: VALIDATED

    Source sequence(s)
    AB024567, AK139324, BC117529
    Consensus CDS
    CCDS27339.1
    UniProtKB/Swiss-Prot
    Q148Q1, Q9QYK4
    UniProtKB/TrEMBL
    Q149R8, Q3UTM4
    Related
    ENSMUSP00000070394.4, ENSMUST00000065904.5
    Conserved Domains (1) summary
    pfam03567
    Location:143409
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    119374902..120226864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519238.5XP_006519301.1  heparan-sulfate 6-O-sulfotransferase 3 isoform X3

    Conserved Domains (1) summary
    cl22970
    Location:143225
    Sulfotransfer_2; Sulfotransferase family
  2. XM_036158750.1XP_036014643.1  heparan-sulfate 6-O-sulfotransferase 3 isoform X1

    Conserved Domains (1) summary
    cl22970
    Location:143225
    Sulfotransfer_2; Sulfotransferase family
  3. XM_011245113.4XP_011243415.1  heparan-sulfate 6-O-sulfotransferase 3 isoform X2

    Conserved Domains (1) summary
    cl22970
    Location:143225
    Sulfotransfer_2; Sulfotransferase family