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ESRRA estrogen related receptor alpha [ Bos taurus (domestic cattle) ]

Gene ID: 507834, updated on 30-Jan-2025
Official Symbol
ESRRAprovided by VGNC
Official Full Name
estrogen related receptor alphaprovided by VGNC
Primary source
VGNC:VGNC:28608
See related
EnsemblRapid:ENSBTAG00070032197
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See ESRRA in Genome Data Viewer
Location:
chromosome: 29
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (42603633..42611807)

Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 4 Neighboring gene catsper channel auxiliary subunit zeta Neighboring gene tRNA methyltransferase activator subunit 11-2 Neighboring gene peroxiredoxin 5 Neighboring gene coiled-coil domain containing 88B

Genomic Sequence:
NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Transcriptional regulators transforming growth factor-β1 and estrogen-related receptor-α identified as putative mediators of calf rumen epithelial tissue development and function during weaning. Connor EE, et al. J Dairy Sci, 2014 Jul. PMID 24767884
  2. Estrogen receptor beta (ERbeta) is expressed differently from ERalpha in bovine placentomes. Schuler G, et al. Exp Clin Endocrinol Diabetes, 2005 Feb. PMID 15772903
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results identify TGFB1 and ESRRA as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.
    Title: Transcriptional regulators transforming growth factor-β1 and estrogen-related receptor-α identified as putative mediators of calf rumen epithelial tissue development and function during weaning.
  2. ERalpha, is only expressed in the caruncle of the placenta.
    Title: Estrogen receptor beta (ERbeta) is expressed differently from ERalpha in bovine placentomes.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables estrogen response element binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in nuclear receptor-mediated steroid hormone signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
steroid hormone receptor ERR1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191373.2 → NP_001178302.1  steroid hormone receptor ERR1

    See identical proteins and their annotated locations for NP_001178302.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000029
    UniProtKB/TrEMBL
    F1MBX3
    Related
    ENSBTAP00070044322.1, ENSBTAT00070072779.1
    Conserved Domains (2) summary
    cd06946
    Location:196 → 419
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:73 → 168
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    42603633..42611807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010821061.4 → XP_010819363.1  steroid hormone receptor ERR1 isoform X1

    See identical proteins and their annotated locations for XP_010819363.1

    UniProtKB/TrEMBL
    F1MBX3
    Related
    ENSBTAP00070044350.1, ENSBTAT00070072825.1
    Conserved Domains (2) summary
    cd06946
    Location:196 → 419
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:73 → 168
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  2. XM_010821062.4 → XP_010819364.1  steroid hormone receptor ERR1 isoform X1

    See identical proteins and their annotated locations for XP_010819364.1

    UniProtKB/TrEMBL
    F1MBX3
    Conserved Domains (2) summary
    cd06946
    Location:196 → 419
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:73 → 168
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
Nucleotide Protein Strain
Heading Accession and Version

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