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C6 complement C6 [ Bos taurus (cattle) ]

Gene ID: 507749, updated on 12-Oct-2019

Summary

Official Symbol
C6provided by VGNC
Official Full Name
complement C6provided by VGNC
Primary source
VGNC:VGNC:52722
See related
BGD:BT10569; Ensembl:ENSBTAG00000014177
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs

Genomic context

Location:
chromosome: 20
Exon count:
19
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 20 NC_037347.1 (33307477..33392975)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 20 AC_000177.1 (33320064..33405582)

Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene transfer RNA tyrosine (anticodon GUA) Neighboring gene phosphatidylinositol specific phospholipase C X domain containing 3 Neighboring gene maestro heat like repeat family member 2B Neighboring gene complement C7

Genomic regions, transcripts, and products

Pathways from BioSystems

  • Complement Activation, Classical Pathway, organism-specific biosystem (from WikiPathways)
    Complement Activation, Classical Pathway, organism-specific biosystemThe complement system is a biochemical cascade that helps, or complements, the ability of antibodies to clear pathogens from an organism. It is part of the immune system called the innate immune syst...
  • Complement and Coagulation Cascades, organism-specific biosystem (from WikiPathways)
    Complement and Coagulation Cascades, organism-specific biosystemBlood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the for...
  • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
    Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Complement and coagulation cascades, conserved biosystem (from KEGG)
    Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Complement cascade, organism-specific biosystem (from REACTOME)
    Complement cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Prion diseases, organism-specific biosystem (from KEGG)
    Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
  • Prion diseases, conserved biosystem (from KEGG)
    Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
  • Regulation of Complement cascade, organism-specific biosystem (from REACTOME)
    Regulation of Complement cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
    Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
  • Systemic lupus erythematosus, conserved biosystem (from KEGG)
    Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
  • Terminal pathway of complement, organism-specific biosystem (from REACTOME)
    Terminal pathway of complement, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Homology

Clone Names

  • MGC137494

Gene Ontology Provided by GOA

Process Evidence Code Pubs
complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
cytolysis IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
membrane attack complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
complement component C6
Names
complement component 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045979.1NP_001039444.1  complement component C6 precursor

    See identical proteins and their annotated locations for NP_001039444.1

    Status: PROVISIONAL

    Source sequence(s)
    BC114014
    UniProtKB/Swiss-Prot
    Q29RU4
    Related
    ENSBTAP00000018845.5, ENSBTAT00000018845.5
    Conserved Domains (6) summary
    cd00033
    Location:644700
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:704755
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    smart00057
    Location:769837
    FIMAC; factor I membrane attack complex
    smart00209
    Location:568612
    TSP1; Thrombospondin type 1 repeats
    smart00457
    Location:313514
    MACPF; membrane-attack complex / perforin
    cd00112
    Location:142173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037347.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    33307477..33392975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010816782.3XP_010815084.2  complement component C6 isoform X1

    Conserved Domains (5) summary
    smart00057
    Location:769837
    FIMAC; factor I membrane attack complex
    smart00209
    Location:568612
    TSP1; Thrombospondin type 1 repeats
    smart00457
    Location:313514
    MACPF; membrane-attack complex / perforin
    cd00112
    Location:142173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl27761
    Location:644764
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  2. XM_010816783.2XP_010815085.2  complement component C6 isoform X1

    Conserved Domains (5) summary
    smart00057
    Location:769837
    FIMAC; factor I membrane attack complex
    smart00209
    Location:568612
    TSP1; Thrombospondin type 1 repeats
    smart00457
    Location:313514
    MACPF; membrane-attack complex / perforin
    cd00112
    Location:142173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl27761
    Location:644764
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
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