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Atp8a2 ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 [ Mus musculus (house mouse) ]

Gene ID: 50769, updated on 23-Jun-2021

Summary

Official Symbol
Atp8a2provided by MGI
Official Full Name
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2provided by MGI
Primary source
MGI:MGI:1354710
See related
Ensembl:ENSMUSG00000021983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
I; a; w; wl; agil; Atpc1b; AI415030
Expression
Broad expression in colon adult (RPKM 3.2), testis adult (RPKM 2.3) and 18 other tissues See more
Orthologs
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Genomic context

See Atp8a2 in Genome Data Viewer
Location:
14; 14 C3- D1
Exon count:
36
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (59884980..60324363, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (59647531..60086914, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (60266578..60705671, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene shisa family member 2 Neighboring gene eukaryotic translation initiation factor 4B pseudogene Neighboring gene RIKEN cDNA 4930563I02 gene Neighboring gene ribosomal protein S2 pseudogene Neighboring gene eukaryotic translation initiation factor 1-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
vestibulomotor degeneration
GeneReviews: Not available
wabbler-lethal
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aminophospholipid flippase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of light stimulus involved in visual perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within eating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within involuntary skeletal muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in neurofilament cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular process controlling posture IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phospholipid translocation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to auditory stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retina layer formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phospholipid-transporting ATPase IB
Names
ATPase 8A2, class I
ATPase 8A2, p type
ATPase class I type 8A member 2
ATPase, class 1, member a
P4-ATPase flippase complex alpha subunit ATP8A2
probable phospholipid-transporting ATPase IB
NP_056618.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015803.3NP_056618.1  phospholipid-transporting ATPase IB

    See identical proteins and their annotated locations for NP_056618.1

    Status: VALIDATED

    Source sequence(s)
    AC123534, AC126684, AC131687, AC159320, AC161375
    Consensus CDS
    CCDS27174.1
    UniProtKB/Swiss-Prot
    P98200
    Related
    ENSMUSP00000079238.6, ENSMUST00000080368.13
    Conserved Domains (6) summary
    TIGR01652
    Location:281066
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:85170
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:466564
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:1779
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:8081059
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:776805
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    59884980..60324363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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