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Tfr2 transferrin receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 50765, updated on 9-Mar-2023

Summary

Official Symbol
Tfr2provided by MGI
Official Full Name
transferrin receptor 2provided by MGI
Primary source
MGI:MGI:1354956
See related
Ensembl:ENSMUSG00000029716 AllianceGenome:MGI:1354956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trfr2
Summary
Predicted to enable co-receptor binding activity and transferrin receptor activity. Acts upstream of or within iron ion homeostasis. Part of HFE-transferrin receptor complex. Is expressed in liver lobe; mesonephros; and urinary system. Used to study hemochromatosis type 3. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 3. Orthologous to human TFR2 (transferrin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 109.9), liver E18 (RPKM 30.7) and 2 other tissues See more
Orthologs
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Genomic context

See Tfr2 in Genome Data Viewer
Location:
5; 5 G2
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137568084..137586343)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137569822..137588081)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), beta 2 Neighboring gene predicted gene 17112 Neighboring gene actin-like 6B Neighboring gene motile sperm domain containing 3 Neighboring gene predicted gene 7285

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables co-receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferrin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transferrin receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to iron ion ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytic iron import into cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endocytic iron import into cell ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intracellular iron ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organismal-level iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptide hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to iron ion ISO
Inferred from Sequence Orthology
more info
 
involved_in transferrin transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of HFE-transferrin receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of HFE-transferrin receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISA
Inferred from Sequence Alignment
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transferrin receptor protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289507.2NP_001276436.2  transferrin receptor protein 2

    Status: VALIDATED

    Source sequence(s)
    AC148018, AK004848, AK165320, AV027736
    Consensus CDS
    CCDS39333.1
    UniProtKB/Swiss-Prot
    Q9CPT2
    Related
    ENSMUSP00000142502.2, ENSMUST00000198783.5
    Conserved Domains (3) summary
    cd02128
    Location:206396
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:404637
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:664788
    TFR_dimer; Transferrin receptor-like dimerization domain
  2. NM_001289509.1NP_001276438.1  transferrin receptor protein 2

    See identical proteins and their annotated locations for NP_001276438.1

    Status: VALIDATED

    Source sequence(s)
    AC148018, AK004965, AV027736
    Consensus CDS
    CCDS39333.1
    UniProtKB/Swiss-Prot
    Q9CPT2, Q9JKX3
    Related
    ENSMUSP00000142478.2, ENSMUST00000199054.5
    Conserved Domains (3) summary
    cd02128
    Location:206396
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:404637
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:664788
    TFR_dimer; Transferrin receptor-like dimerization domain
  3. NM_001289511.1NP_001276440.1  transferrin receptor protein 2

    See identical proteins and their annotated locations for NP_001276440.1

    Status: VALIDATED

    Source sequence(s)
    AC148018
    Consensus CDS
    CCDS39333.1
    UniProtKB/Swiss-Prot
    Q9CPT2, Q9JKX3
    Related
    ENSMUSP00000142814.2, ENSMUST00000196471.5
    Conserved Domains (3) summary
    cd02128
    Location:206396
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:404637
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:664788
    TFR_dimer; Transferrin receptor-like dimerization domain
  4. NM_001359206.1NP_001346135.1  transferrin receptor protein 2

    Status: VALIDATED

    Source sequence(s)
    AC148018
    Consensus CDS
    CCDS39333.1
    UniProtKB/Swiss-Prot
    Q9CPT2
    Related
    ENSMUSP00000142720.2, ENSMUST00000198866.5
    Conserved Domains (3) summary
    cd02128
    Location:206396
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:404637
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:664788
    TFR_dimer; Transferrin receptor-like dimerization domain
  5. NM_015799.4NP_056614.3  transferrin receptor protein 2

    See identical proteins and their annotated locations for NP_056614.3

    Status: VALIDATED

    Source sequence(s)
    AC148018, AK004848, AV027736
    Consensus CDS
    CCDS39333.1
    UniProtKB/Swiss-Prot
    Q9CPT2, Q9JKX3
    Related
    ENSMUSP00000031729.9, ENSMUST00000031729.13
    Conserved Domains (3) summary
    cd02128
    Location:206396
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:404637
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:664788
    TFR_dimer; Transferrin receptor-like dimerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137568084..137586343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504593.4XP_006504656.1  transferrin receptor protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006504656.1

    UniProtKB/Swiss-Prot
    Q9CPT2, Q9JKX3
    Conserved Domains (3) summary
    cd02128
    Location:206396
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:404637
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:664788
    TFR_dimer; Transferrin receptor-like dimerization domain
  2. XM_030254655.1XP_030110515.1  transferrin receptor protein 2 isoform X1

    Conserved Domains (3) summary
    cd02128
    Location:248438
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:446679
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:706830
    TFR_dimer; Transferrin receptor-like dimerization domain
  3. XM_006504594.4XP_006504657.1  transferrin receptor protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006504657.1

    UniProtKB/Swiss-Prot
    Q9CPT2, Q9JKX3
    Conserved Domains (3) summary
    cd02128
    Location:206396
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:404637
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:664788
    TFR_dimer; Transferrin receptor-like dimerization domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_152864.1: Suppressed sequence

    Description
    NR_152864.1: This RefSeq has been removed because currently there is insufficient support for this transcript.